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Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
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Caffeine is the most widely consumed behaviorally active substance in the world and almost all caffeine comes from dietary sources (beverages and food).Abstract:
Caffeine is the most widely consumed behaviorally active substance in the world. Almost all caffeine comes from dietary sources (beverages and food), most of it from coffee and tea. Acute and, especially, chronic caffeine intake appear to have only minor negative consequences on health. For thisread more
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Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain.
Nora D. Volkow,Gene-Jack Wang,Jean Logan,D. Alexoff,Joanna S. Fowler,Panayotis K. Thanos,Christopher Wong,Vicent Casadó,Sergi Ferré,Dardo Tomasi +9 more
TL;DR: The findings indicate that in the human brain, caffeine, at doses typically consumed, increases the availability of DA D2/D3 receptors, which indicates that caffeine does not increase DA in the striatum for this would have decreased D2-D3 receptor availability.
Journal ArticleDOI
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.
TL;DR: The data indicate that SUDEP is due to overactivation of adenosine receptors and that caffeine treatment after seizure onset might be beneficial, and that caffeinated drinks following seizure onset may be beneficial.
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Caffeine Use Disorder: A Comprehensive Review and Research Agenda
TL;DR: A comprehensive literature review on the biological evidence for caffeine dependence can be found in this article, where the authors provide a systematic review of the prevalence of caffeine dependence and rates of endorsement of clinically meaningful indicators of distress and functional impairment among habitual caffeine users.
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Challenging sleep in aging: the effects of 200 mg of caffeine during the evening in young and middle-aged moderate caffeine consumers
Caroline Drapeau,Isabelle Hamel-Hébert,Rébecca Robillard,Brahim Selmaoui,Daniel Filipini,Julie Carrier +5 more
TL;DR: Caffeine produced similar effects in young and middle‐aged subjects and sleep EEG results do not entirely support the hypothesis that caffeine fully mimics the effects of a reduction of homeostatic sleep propensity when following a normal sleep–wake cycle.
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Pre-exercise nutrition: the role of macronutrients, modified starches and supplements on metabolism and endurance performance.
TL;DR: There is some evidence to suggest enhanced pre-exercise glycogen synthesis and benefits to metabolism during exercise during exercise, and various supplements also warrant possible inclusion into pre-race nutrition for endurance athletes.
References
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IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
TL;DR: This timely monograph is a distillation of knowledge of hepatitis B, C and D, based on a review of 1000 studies by a small group of scientists, and it is concluded that hepatitis D virus cannot be classified as a human carcinogen.
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A Neural Substrate of Prediction and Reward
TL;DR: Findings in this work indicate that dopaminergic neurons in the primate whose fluctuating output apparently signals changes or errors in the predictions of future salient and rewarding events can be understood through quantitative theories of adaptive optimizing control.