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Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
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Caffeine is the most widely consumed behaviorally active substance in the world and almost all caffeine comes from dietary sources (beverages and food).Abstract:
Caffeine is the most widely consumed behaviorally active substance in the world. Almost all caffeine comes from dietary sources (beverages and food), most of it from coffee and tea. Acute and, especially, chronic caffeine intake appear to have only minor negative consequences on health. For thisread more
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Treatment with A 2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage
Raquel Boia,Filipe Elvas,Maria H. Madeira,Inês Dinis Aires,Ana C. Rodrigues-Neves,Pedro Tralhão,Eszter Szabó,Younis Baqi,Christa E. Müller,Ângelo R. Tomé,Rodrigo A. Cunha,António F. Ambrósio,Ana Raquel Santiago +12 more
TL;DR: A selective A2AR antagonist (KW6002) is evaluated against the damage elicited by ischemia–reperfusion and the effect of caffeine on the regulation of microglia-mediated neuroinflammation in the transient ischemic model is demonstrated.
Journal ArticleDOI
Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms
Xiangpeng Ren,Jiang-Fan Chen +1 more
TL;DR: Caffeine has been shown to not only be neuroprotective but also motor and non-motor (cognitive) benefits in Parkinson's disease (PD) as discussed by the authors.
Journal ArticleDOI
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: Evidence for a role of the adenosinergic system
Daniel Martins,Leidiane Mazzardo-Martins,F. Soldi,Juliana Stramosk,Anna Paula Piovezan,Adair R.S. Santos +5 more
TL;DR: This is the first report demonstrating that repeated sessions of high-intensity swimming exercise attenuate mechanical allodynia in an animal model of CRPS-I and that the mechanism involves endogenous adenosine andAdenosine A receptors.
Book ChapterDOI
Adenosine and Sleep
Michael Lazarus,Jiang-Fan Chen,Jiang-Fan Chen,Zhi-Li Huang,Yoshihiro Urade,Bertil B. Fredholm +5 more
TL;DR: A summary of current knowledge of the role of adenosine and its receptors in the regulation of sleep and wakefulness and the possible use of more selective adenosinergic drugs for the treatment of sleep disorders is presented.
Journal ArticleDOI
Subchronic caffeine exposure induces sensitization to caffeine and cross-sensitization to amphetamine ipsilateral turning behavior independent from dopamine release
TL;DR: The results are the first demonstration that caffeine pre-exposure sensitizes the motor-stimulant effects of caffeine itself and of amphetamine and postsynaptic modifications in dopamine and adenosine receptor interaction might be involved in the sensitization phenomena observed.
References
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IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
TL;DR: This timely monograph is a distillation of knowledge of hepatitis B, C and D, based on a review of 1000 studies by a small group of scientists, and it is concluded that hepatitis D virus cannot be classified as a human carcinogen.
Journal ArticleDOI
A Neural Substrate of Prediction and Reward
TL;DR: Findings in this work indicate that dopaminergic neurons in the primate whose fluctuating output apparently signals changes or errors in the predictions of future salient and rewarding events can be understood through quantitative theories of adaptive optimizing control.