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Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
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Caffeine is the most widely consumed behaviorally active substance in the world and almost all caffeine comes from dietary sources (beverages and food).Abstract:
Caffeine is the most widely consumed behaviorally active substance in the world. Almost all caffeine comes from dietary sources (beverages and food), most of it from coffee and tea. Acute and, especially, chronic caffeine intake appear to have only minor negative consequences on health. For thisread more
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International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
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The Role and Regulation of Adenosine in the Central Nervous System
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A2A adenosine receptor protects tumors from antitumor T cells
Akio Ohta,Elieser Gorelik,Simon J. Prasad,Franca Ronchese,Dmitriy Lukashev,Dmitriy Lukashev,Michael K.K. Wong,Michael K.K. Wong,Xiaojun Huang,Sheila A. Caldwell,Kebin Liu,Kebin Liu,Patrick F. Smith,Jiang-Fan Chen,Edwin K. Jackson,Sergey Apasov,Scott I. Abrams,Michail V. Sitkovsky,Michail V. Sitkovsky +18 more
TL;DR: Although using the hypoxia→adenosine→A2AR pathway inhibitors may improve antitumor immunity, the recruitment of this pathway by selective drugs is expected to attenuate the autoimmune tissue damage.
References
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Effects of caffeine on cigarette smoking and subjective response
TL;DR: Results demonstrate that caffeine and d‐amphetamine have different effects on cigarette‐smoking behavior as well as on subjective response and suggest that the positive correlation between cigarette smoking and coffee drinking is not the result of a simple pharmacologic effect of caffeine.
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Caffeine self-administration and withdrawal: incidence, individual differences and interrelationships
TL;DR: Data is collated from four prior studies to examine the incidence and predictors of the occurrence of caffeine self-administration and withdrawal and several variables (e.g., average caffeine intake) did not predict caffeine self,administration or withdrawal.
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Reinforcing effects of nicotine in humans and experimental animals responding under intermittent schedules of IV drug injection
TL;DR: The results confirm that nicotine can function to control behavior by serving as a reinforcer for animals and humans and suggest that commonly used tobacco products function as ideal nicotine delivery systems for controlling behavior.
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Antagonistic effects of caffeine and yohimbine in animal tests of anxiety.
TL;DR: Unexpectedly, caffeine and yohimbine antagonized each others' effects in the social interaction and elevated plus-maze tests of anxiety.
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Activation of junB by PKC and PKA signal transduction through a novel cis-acting element
TL;DR: In this article, the junB gene was cloned from a genomic testis library, and the mouse junB promoter was shown to be activated by serum, TPA, and activated PKA.