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Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use

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TLDR
Caffeine is the most widely consumed behaviorally active substance in the world and almost all caffeine comes from dietary sources (beverages and food).
Abstract
Caffeine is the most widely consumed behaviorally active substance in the world. Almost all caffeine comes from dietary sources (beverages and food), most of it from coffee and tea. Acute and, especially, chronic caffeine intake appear to have only minor negative consequences on health. For this

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Caffeine effects on systemic metabolism, oxidative-inflammatory pathways, and exercise performance

TL;DR: This review summarizes the most relevant classical and current literature available regarding the use of caffeine in different metabolic situations, such as oxidative and inflammatory status, as well as anaerobic and aerobic physical exercises.
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Adenosine receptors in neurological disorders

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Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles.

TL;DR: Test the hypothesis that caffeine and theophylline inhibit insulin‐stimulated glucose uptake in skeletal muscles by inhibiting phosphatidylinositol 3‐kinase activity and insulin‐ stimulated protein kinase B phosphorylation.
References
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IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

TL;DR: This timely monograph is a distillation of knowledge of hepatitis B, C and D, based on a review of 1000 studies by a small group of scientists, and it is concluded that hepatitis D virus cannot be classified as a human carcinogen.
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A Neural Substrate of Prediction and Reward

TL;DR: Findings in this work indicate that dopaminergic neurons in the primate whose fluctuating output apparently signals changes or errors in the predictions of future salient and rewarding events can be understood through quantitative theories of adaptive optimizing control.
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Trending Questions (1)
Does caffeine consumption limit the blood supply to the brain?

No, caffeine consumption does not limit the blood supply to the brain.