Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Timothy Davern,Naga Chalasani,Robert J. Fontana,Paul H. Hayashi,Petr Protiva,David E. Kleiner,Ronald E. Engle,Hanh Nguyen,Suzanne U. Emerson,Robert H. Purcell,Hans L. Tillmann,Jiezhun Gu,Jose Serrano,Jay H. Hoofnagle +13 more
TLDR
HEV infection contributes to a small but important proportion of cases of acute liver injury that are suspected to be drug induced, andSerologic testing for HEV infection should be performed, particularly if clinical features are compatible with acute viral hepatitis.About:
This article is published in Gastroenterology.The article was published on 2011-11-01 and is currently open access. It has received 295 citations till now. The article focuses on the topics: Hepatitis E & Viral hepatitis.read more
Citations
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Journal ArticleDOI
Hepatitis E: A Literature Review.
Juliana Ayres de Alencar Arrais Guerra,Katia Cristina Kampa,Daphne Gonçalves Benatti Morsoletto,Alcindo Pissaia Junior,Cláudia Alexandra Pontes Ivantes +4 more
TL;DR: A literature review of hepatitis E and the relation between chronic liver disease and transplantation is presented, especially in patients who underwent transplantation, have hematological malignancies requiring chemotherapy, or have infection with the human immunodeficiency virus.
Journal ArticleDOI
Diagnostic and prognostic assessment of suspected drug-induced liver injury in clinical practice
TL;DR: The best diagnostic and prognostic approach of a DILI suspicion is discussed by judiciously choosing and interpreting the standard tests currently used in clinical practice.
Journal ArticleDOI
Hepatic Damage by Natural Remedies
Raúl J. Andrade,Inmaculada Medina-Caliz,A. González-Jiménez,Miren García-Cortés,M. Isabel Lucena +4 more
TL;DR: Collaborative efforts to retrieve detailed phenotypic data and biological samples of patients with HILI would facilitate genomic and other molecular approaches for a better understanding of host risk factors and, hopefully, for biomarker identification.
Journal ArticleDOI
Drug-Induced Liver Injury: Expanding Our Knowledge by Enlarging Population Analysis With Prospective and Scoring Causality Assessment
Rolf Teschke,Raúl J. Andrade +1 more
TL;DR: See “Features and outcomes of 889 patients with drug-induced liver injury: The DILIN Prospective Study,” by Chalasani, N, Bonkovsky HL, Fontana R, et al.
Journal ArticleDOI
Pathobiology of hepatitis E: lessons learned from primate models.
Robert H. Purcell,Ronald E. Engle,Sugantha Govindarajan,Richard Herbert,Marisa St. Claire,William R. Elkins,Anthony Cook,Charlene K. Shaver,Michelle Beauregard,Joanne Swerczek,Suzanne U. Emerson +10 more
TL;DR: The biological parameters of hepatitis E have been studied in nonhuman primates, which are surrogates of man and chimpanzees, and the biological characteristics of the different HEV genotypes mirrored their epidemiological characteristics.
References
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Journal ArticleDOI
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
TL;DR: In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.
Journal ArticleDOI
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Journal ArticleDOI
A novel virus in swine is closely related to the human hepatitis E virus
Xiang-Jin Meng,Robert H. Purcell,Patrick G. Halbur,James R. Lehman,Dale M. Webb,Tatiana S. Tsareva,Joseph S. Haynes,Brad J. Thacker,Suzanne U. Emerson +8 more
TL;DR: The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs.
Journal ArticleDOI
Hepatitis E virus.
TL;DR: Hepatitis E virus is an enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis in many countries of Asia and Africa but only rarely causes disease in more industrialised countries.
Journal ArticleDOI
Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States
Naga Chalasani,Robert J. Fontana,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Paul B. Watkins,Timothy J. Davern,Jose Serrano,Hongqiu Yang,James Rochon +9 more
TL;DR: This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled in a prospective study to recruit patients with suspected idiosyncratic drug-induced liver injury and create a repository of biological samples for analysis.
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