Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Timothy Davern,Naga Chalasani,Robert J. Fontana,Paul H. Hayashi,Petr Protiva,David E. Kleiner,Ronald E. Engle,Hanh Nguyen,Suzanne U. Emerson,Robert H. Purcell,Hans L. Tillmann,Jiezhun Gu,Jose Serrano,Jay H. Hoofnagle +13 more
TLDR
HEV infection contributes to a small but important proportion of cases of acute liver injury that are suspected to be drug induced, andSerologic testing for HEV infection should be performed, particularly if clinical features are compatible with acute viral hepatitis.About:
This article is published in Gastroenterology.The article was published on 2011-11-01 and is currently open access. It has received 295 citations till now. The article focuses on the topics: Hepatitis E & Viral hepatitis.read more
Citations
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Journal ArticleDOI
Incidence and prevalence of acute hepatitis E virus infection in patients with suspected Drug-Induced Liver Injury in the Spanish DILI Registry
Judith Sanabria-Cabrera,Rocio Sanjuan-Jimenez,Encarnación Clavijo,Inmaculada Medina-Caliz,A. González-Jiménez,Miren García-Cortés,Aida Ortega-Alonso,Miguel Jiménez-Pérez,Rocío González-Grande,Camilla Stephens,Mercedes Robles-Díaz,M. Isabel Lucena,Raúl J. Andrade,Spanish Dili Registry +13 more
TL;DR: The aims of this study were to establish the role of HEV infection and its phenotypic presentation in patients initially suspected of DILI and to determine the anti‐HEV seroprevalence rate.
Book ChapterDOI
Clinical Considerations of Drug-Induced Hepatotoxicity
S. Jain,N. Kaplowitz +1 more
TL;DR: Some drugs cause elevations in serum aminotransferases but rarely, if ever, cause jaundice, and emphasis is placed on prevention and recognition of DILI early in the course of treatment.
Journal ArticleDOI
Hepatitis E Virus Infection in the United States: Current Understanding of the Prevalence and Significance in the Liver Transplant Patient Population and Proposed Diagnostic and Treatment Strategies.
TL;DR: The current knowledge of HEV as it pertains to the liver transplant patient population is discussed and diagnosis and treatment of this infection are discussed.
Journal ArticleDOI
Detection of viral hepatitis E in clinical liver biopsies.
Sandrine Prost,Claire Crossan,Harry R. Dalton,Robert A. de Man,Nassim Kamar,Janick Selves,Catharine A Dhaliwal,Linda Scobie,Christopher Bellamy +8 more
TL;DR: To determine the relative utility of in‐situ testing for hepatitis E virus (HEV) RNA and paraffin‐section polymerase chain reaction (PCR) to diagnose HEV infection in paraffIn‐embedded clinical liver biopsies, and to correlate with clinicopathological characteristics, a large number of patients were surveyed.
Journal ArticleDOI
Development of a novel histologic diagnostic algorithm for hepatic graft-versus-host disease.
TL;DR: This work identified histologic features with specificity for hepatic graft-versus-host disease and developed a simple algorithm for pathologists to predict its likelihood, distinguishing this critical diagnosis promptly from mimickers having vastly different treatments and prognoses.
References
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Journal ArticleDOI
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
TL;DR: In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.
Journal ArticleDOI
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Journal ArticleDOI
A novel virus in swine is closely related to the human hepatitis E virus
Xiang-Jin Meng,Robert H. Purcell,Patrick G. Halbur,James R. Lehman,Dale M. Webb,Tatiana S. Tsareva,Joseph S. Haynes,Brad J. Thacker,Suzanne U. Emerson +8 more
TL;DR: The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs.
Journal ArticleDOI
Hepatitis E virus.
TL;DR: Hepatitis E virus is an enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis in many countries of Asia and Africa but only rarely causes disease in more industrialised countries.
Journal ArticleDOI
Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States
Naga Chalasani,Robert J. Fontana,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Paul B. Watkins,Timothy J. Davern,Jose Serrano,Hongqiu Yang,James Rochon +9 more
TL;DR: This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled in a prospective study to recruit patients with suspected idiosyncratic drug-induced liver injury and create a repository of biological samples for analysis.
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