Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Timothy Davern,Naga Chalasani,Robert J. Fontana,Paul H. Hayashi,Petr Protiva,David E. Kleiner,Ronald E. Engle,Hanh Nguyen,Suzanne U. Emerson,Robert H. Purcell,Hans L. Tillmann,Jiezhun Gu,Jose Serrano,Jay H. Hoofnagle +13 more
TLDR
HEV infection contributes to a small but important proportion of cases of acute liver injury that are suspected to be drug induced, andSerologic testing for HEV infection should be performed, particularly if clinical features are compatible with acute viral hepatitis.About:
This article is published in Gastroenterology.The article was published on 2011-11-01 and is currently open access. It has received 295 citations till now. The article focuses on the topics: Hepatitis E & Viral hepatitis.read more
Citations
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Dosing ribavirin in hepatitis E-infected solid organ transplant recipients.
TL;DR: An overview of HEV epidemiology, its mode of transmission and clinical manifestations, as well as its treatment by ribavirin with a focus on the drug's pharmacokinetics and dosing is provided.
Journal ArticleDOI
Fatal autochthonous fulminant hepatitis E early after allogeneic stem cell transplantation.
Martin Carre,Anne Thiebaut-Bertrand,Sylvie Larrat,Vincent Leroy,Patricia Pouzol,N Sturm,Sébastien Lhomme,J. Y. Cahn,Frédéric Garban,Patrice Morand +9 more
TL;DR: In immunocompromised patients such as solid organ transplant (SOT) recipients, patients suffering from hematological malignancies treated by chemotherapy and/or stem cell transplantation and more rarely from HIV, HEV infections have been reported to cause chronic hepatitis rapidly leading to cirrhosis.
Journal Article
Three cases of liver toxicity with a dietary supplement intended to stop hair loss
TL;DR: It is highlighted the importance of awareness regarding these substances at history taking in order to identify and report hepatic adverse reactions secondary to apparently safe herbs as described in the present manuscript.
Alanine Amino Transferase
Kevin E. Moriles,Samy A. Azer +1 more
TL;DR: The elevation of serum ALT concentration is a sensitive but not specific measure of hepatocellular injury, as the degree of elevation can not determine the exact cause.
Journal ArticleDOI
Hepatitis E: latest developments in knowledge
TL;DR: It has been confirmed that hepatitis E is a zoonosis and that parenteral transmission can also occur and treatment with ribavirin and/or pegylated-IFN-α have proven to be successful in some cases.
References
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Journal ArticleDOI
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
TL;DR: In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.
Journal ArticleDOI
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Journal ArticleDOI
A novel virus in swine is closely related to the human hepatitis E virus
Xiang-Jin Meng,Robert H. Purcell,Patrick G. Halbur,James R. Lehman,Dale M. Webb,Tatiana S. Tsareva,Joseph S. Haynes,Brad J. Thacker,Suzanne U. Emerson +8 more
TL;DR: The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs.
Journal ArticleDOI
Hepatitis E virus.
TL;DR: Hepatitis E virus is an enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis in many countries of Asia and Africa but only rarely causes disease in more industrialised countries.
Journal ArticleDOI
Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States
Naga Chalasani,Robert J. Fontana,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Paul B. Watkins,Timothy J. Davern,Jose Serrano,Hongqiu Yang,James Rochon +9 more
TL;DR: This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled in a prospective study to recruit patients with suspected idiosyncratic drug-induced liver injury and create a repository of biological samples for analysis.
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