Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Timothy Davern,Naga Chalasani,Robert J. Fontana,Paul H. Hayashi,Petr Protiva,David E. Kleiner,Ronald E. Engle,Hanh Nguyen,Suzanne U. Emerson,Robert H. Purcell,Hans L. Tillmann,Jiezhun Gu,Jose Serrano,Jay H. Hoofnagle +13 more
TLDR
HEV infection contributes to a small but important proportion of cases of acute liver injury that are suspected to be drug induced, andSerologic testing for HEV infection should be performed, particularly if clinical features are compatible with acute viral hepatitis.About:
This article is published in Gastroenterology.The article was published on 2011-11-01 and is currently open access. It has received 295 citations till now. The article focuses on the topics: Hepatitis E & Viral hepatitis.read more
Citations
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Journal ArticleDOI
Protective Effect of Gemfibrozil on Hepatotoxicity Induced by Acetaminophen in Mice: the Importance of Oxidative Stress Suppression.
Hojatolla Nikravesh,Mohammad Javad Khodayar,Masoud Mahdavinia,Esrafil Mansouri,Leila Zeidooni,Fereshteh Negad Dehbashi +5 more
TL;DR: Investigation of the protective effect of GEM on acute liver toxicity induced by acetaminophen in mice demonstrated that GEM has antioxidant properties and can protect the liver from APAP toxicity, just in the same pathway that toxicity occurs by toxic ROS.
Book ChapterDOI
Causality Assessment Methods in Drug-Induced Liver Injury
Rolf Teschke,Gaby Danan +1 more
Journal ArticleDOI
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
Robert J. Fontana,Iris Liou,Adrian Reuben,Ayako Suzuki,Isabel Fiel,William Lee,Victor J. Navarro +6 more
TL;DR: Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA University of Washington, Seattle, Washington, USA Department of Medicine, Medical University of South Carolina, Charleston, South Carolina as mentioned in this paper .
Journal ArticleDOI
Transfusion-transmitted hepatitis E in a patient with myelodysplastic syndromes.
Yukihiko Kimura,Akihiko Gotoh,Seiichiro Katagiri,Yuji Hoshi,Shigeharu Uchida,Atsushi Yamasaki,Yoko Takahashi,Katsuyuki Fukutake,Toru Kiguchi,Kazuma Ohyashiki +9 more
TL;DR: The case of a patient with a myelodysplastic syndrome who developed acute hepatitis due to transfusion-transmitted HEV infection is reported and the literature on the topic is reviewed.
Journal ArticleDOI
Transfusion-associated hepatitis before the screening of blood for hepatitis risk factors.
Ronald E. Engle,Jens Bukh,Jens Bukh,Harvey J. Alter,Suzanne U. Emerson,Joni Trenbeath,Hanh Nguyen,Alicia Brockington,Tanaji Mitra,Robert H. Purcell +9 more
TL;DR: The aims were to reevaluate blood recipients receiving unscreened blood and analyze hepatitis viruses circulating more than 45 years ago to determine the true incidence of transfusion‐associated hepatitis.
References
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Journal ArticleDOI
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
TL;DR: In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.
Journal ArticleDOI
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Journal ArticleDOI
A novel virus in swine is closely related to the human hepatitis E virus
Xiang-Jin Meng,Robert H. Purcell,Patrick G. Halbur,James R. Lehman,Dale M. Webb,Tatiana S. Tsareva,Joseph S. Haynes,Brad J. Thacker,Suzanne U. Emerson +8 more
TL;DR: The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs.
Journal ArticleDOI
Hepatitis E virus.
TL;DR: Hepatitis E virus is an enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis in many countries of Asia and Africa but only rarely causes disease in more industrialised countries.
Journal ArticleDOI
Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States
Naga Chalasani,Robert J. Fontana,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Paul B. Watkins,Timothy J. Davern,Jose Serrano,Hongqiu Yang,James Rochon +9 more
TL;DR: This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled in a prospective study to recruit patients with suspected idiosyncratic drug-induced liver injury and create a repository of biological samples for analysis.
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