Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Timothy Davern,Naga Chalasani,Robert J. Fontana,Paul H. Hayashi,Petr Protiva,David E. Kleiner,Ronald E. Engle,Hanh Nguyen,Suzanne U. Emerson,Robert H. Purcell,Hans L. Tillmann,Jiezhun Gu,Jose Serrano,Jay H. Hoofnagle +13 more
TLDR
HEV infection contributes to a small but important proportion of cases of acute liver injury that are suspected to be drug induced, andSerologic testing for HEV infection should be performed, particularly if clinical features are compatible with acute viral hepatitis.About:
This article is published in Gastroenterology.The article was published on 2011-11-01 and is currently open access. It has received 295 citations till now. The article focuses on the topics: Hepatitis E & Viral hepatitis.read more
Citations
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Journal ArticleDOI
Molecular detection of hepatitis E virus (HEV) in liver biopsies after liver transplantation.
Ulrike Protzer,Friederike Böhm,Thomas Longerich,Judith Seebach,Mojdeh Heidary Navid,Juliane Friemel,Ewerton Marques-Maggio,Marion Bawohl,Mathias Heikenwalder,Peter Schirmacher,Philipp Dutkowski,Pierre-Alain Clavien,Peter Schemmer,Paul Schnitzler,Daniel Gotthardt,Beat Müllhaupt,Achim Weber +16 more
TL;DR: The data confirm that HEV infection is a relevant cause of liver injury after liver transplantation and molecular testing for HEV in routinely processed transplant liver biopsies is powerful for evaluating patients with elevated transaminases of unknown origin.
Journal ArticleDOI
Severe hepatic injury associated with different statins in patients with chronic liver disease: a nationwide population-based cohort study.
TL;DR: The hepatotoxicity of statins in patients with chronic liver diseases remains unclear and the risk of severe hepatic injury associated with different statins is estimated.
Journal ArticleDOI
Epidemiology and Transmission of Hepatitis A Virus and Hepatitis E Virus Infections in the United States.
TL;DR: There are many similarities in the epidemiology and transmission of hepatitis A virus (HAV) and hepatitis E virus (HEV) genotype (gt)3 infections in the United States, although specific routes of transmission are more clearly established for HAV than for HEV.
Journal Article
An update on hepatitis B, D, and E viruses.
TL;DR: This article summarizes a presentation by Jennifer Price, MD, at the IAS-USA continuing education program held in San Francisco, California, in June 2013, and describes the mainstay of treatment for HDV infection is peginterferon alfa for at least 48 weeks.
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Hepatitis E infection in liver transplant recipients
Alberto Unzueta,Jorge Rakela +1 more
TL;DR: There are not enough data to recommend treatment with ribavirin for adult liver transplant recipients, although this has been tried in other SOT populations, and a decrease in immunosuppression is considered the first line of treatment, and pegylated interferon can be considered the second line of treated.
References
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Journal ArticleDOI
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
TL;DR: In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.
Journal ArticleDOI
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Journal ArticleDOI
A novel virus in swine is closely related to the human hepatitis E virus
Xiang-Jin Meng,Robert H. Purcell,Patrick G. Halbur,James R. Lehman,Dale M. Webb,Tatiana S. Tsareva,Joseph S. Haynes,Brad J. Thacker,Suzanne U. Emerson +8 more
TL;DR: The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs.
Journal ArticleDOI
Hepatitis E virus.
TL;DR: Hepatitis E virus is an enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis in many countries of Asia and Africa but only rarely causes disease in more industrialised countries.
Journal ArticleDOI
Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States
Naga Chalasani,Robert J. Fontana,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Paul B. Watkins,Timothy J. Davern,Jose Serrano,Hongqiu Yang,James Rochon +9 more
TL;DR: This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled in a prospective study to recruit patients with suspected idiosyncratic drug-induced liver injury and create a repository of biological samples for analysis.
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