Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Timothy Davern,Naga Chalasani,Robert J. Fontana,Paul H. Hayashi,Petr Protiva,David E. Kleiner,Ronald E. Engle,Hanh Nguyen,Suzanne U. Emerson,Robert H. Purcell,Hans L. Tillmann,Jiezhun Gu,Jose Serrano,Jay H. Hoofnagle +13 more
TLDR
HEV infection contributes to a small but important proportion of cases of acute liver injury that are suspected to be drug induced, andSerologic testing for HEV infection should be performed, particularly if clinical features are compatible with acute viral hepatitis.About:
This article is published in Gastroenterology.The article was published on 2011-11-01 and is currently open access. It has received 295 citations till now. The article focuses on the topics: Hepatitis E & Viral hepatitis.read more
Citations
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An assessment by the Statin Liver Safety Task Force: 2014 update
TL;DR: This panel provides diagnostic and algorithmic approaches when evaluating statin-treated patients who experience elevations in liver enzymes, including the value of baseline liver enzymes before initiating statin therapy, and safety of statin use in patients with nonalcoholic fatty liver disease.
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Idiosyncratic Drug-Induced Liver Injury Is Associated With Substantial Morbidity and Mortality Within 6 Months From Onset
Robert J. Fontana,Paul H. Hayashi,Jiezhun Gu,K. Rajender Reddy,Huiman X. Barnhart,Paul B. Watkins,Jose Serrano,William M. Lee,Naga Chalasani,Andrew Stolz,Timothy Davern,Jayant A. Talwakar +11 more
TL;DR: The profile of liver injury at presentation, initial severity, patient's race, and medical comorbidities are important determinants of the likelihood of death/transplantation or persistent liver injury within 6 months of DILI onset.
Journal ArticleDOI
Drug-induced Acute Liver Failure
TL;DR: Although acute liver failure caused by drug-induced liver injury comprises a small fraction of overall drug induced liver injury, these patients require high resource use and have relatively poor outcomes as mentioned in this paper.
Journal ArticleDOI
Antidepressant-induced liver injury: a review for clinicians
TL;DR: Although an infrequent event, DILI from antidepressant drugs may be irreversible, and clinicians should be aware of it, and prompt discontinuation of the drug responsible is essential.
Journal ArticleDOI
Hepatitis E virus infection among solid organ transplant recipients, the Netherlands
Suzan D. Pas,Robert A. de Man,Claudia Mulders,Aggie H.M.M. Balk,Peter Th. W. van Hal,Willem Weimar,Marion Koopmans,Albert D. M. E. Osterhaus,Annemiek A. van der Eijk +8 more
TL;DR: This immunocompromised population is at risk for hepatitis E virus infection, and living heart, lung, liver, Liver, and kidney transplant recipients are screened by reverse transcription PCR.
References
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Journal ArticleDOI
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
TL;DR: In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.
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Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Journal ArticleDOI
A novel virus in swine is closely related to the human hepatitis E virus
Xiang-Jin Meng,Robert H. Purcell,Patrick G. Halbur,James R. Lehman,Dale M. Webb,Tatiana S. Tsareva,Joseph S. Haynes,Brad J. Thacker,Suzanne U. Emerson +8 more
TL;DR: The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs.
Journal ArticleDOI
Hepatitis E virus.
TL;DR: Hepatitis E virus is an enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis in many countries of Asia and Africa but only rarely causes disease in more industrialised countries.
Journal ArticleDOI
Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States
Naga Chalasani,Robert J. Fontana,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Paul B. Watkins,Timothy J. Davern,Jose Serrano,Hongqiu Yang,James Rochon +9 more
TL;DR: This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled in a prospective study to recruit patients with suspected idiosyncratic drug-induced liver injury and create a repository of biological samples for analysis.
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