Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Timothy Davern,Naga Chalasani,Robert J. Fontana,Paul H. Hayashi,Petr Protiva,David E. Kleiner,Ronald E. Engle,Hanh Nguyen,Suzanne U. Emerson,Robert H. Purcell,Hans L. Tillmann,Jiezhun Gu,Jose Serrano,Jay H. Hoofnagle +13 more
TLDR
HEV infection contributes to a small but important proportion of cases of acute liver injury that are suspected to be drug induced, andSerologic testing for HEV infection should be performed, particularly if clinical features are compatible with acute viral hepatitis.About:
This article is published in Gastroenterology.The article was published on 2011-11-01 and is currently open access. It has received 295 citations till now. The article focuses on the topics: Hepatitis E & Viral hepatitis.read more
Citations
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Journal ArticleDOI
Liver Injury from Herbal, Dietary, and Weight Loss Supplements: a Review.
TL;DR: Case reports of weight loss products such as Hydroxycut and OxyElite Pro are highlighted as one form of HDS that have hepatotoxic potential and its clinical effects as well as pattern of liver injury are characterized to outline a diagnostic approach for identifying any drug induced liver injury.
Journal ArticleDOI
Summary of the British Transplantation Society UK Guidelines for Hepatitis E and Solid Organ Transplantation
Stuart McPherson,Ahmed M. Elsharkawy,Michael Ankcorn,Samreen Ijaz,James J. Powell,Ian A. Rowe,Richard S. Tedder,Peter A. Andrews +7 more
TL;DR: The evidence relating to the diagnosis and management of persistent hepatitis E in solid organ transplant recipients and the methods of prevention of HEV infection are reviewed.
Journal ArticleDOI
Acute Liver Injury due to Flavocoxid (Limbrel), a Medical Food for Osteoarthritis: A Case Series
Naga Chalasani,Raj Vuppalanchi,Victor Navarro,Robert J. Fontana,Herbert L. Bonkovsky,Huiman X. Barnhart,David E. Kleiner,Jay H. Hoofnagle +7 more
TL;DR: Flavocoxid can cause clinically significant liver injury, which seems to resolve within weeks after cessation, and all patients recovered without experiencing acute liver failure or chronic liver injury.
Journal ArticleDOI
Risk of zoonotic transmission of HEV from rabbits
Sébastien Lhomme,Martine Dubois,Florence Abravanel,Sokunthea Top,Stéphane Bertagnoli,Stéphane Bertagnoli,Jean-Luc Guérin,Jean-Luc Guérin,Jacques Izopet +8 more
TL;DR: The ability of rabbit HEV to cause cross-species infection in a pig model has recently been demonstrated and data support the possibility of zoonotic transmission of HEV from rabbits.
Journal ArticleDOI
The role of hepatitis E virus infection in adult Americans with acute liver failure.
Robert J. Fontana,Ronald E. Engle,Steven Scaglione,Victor Araya,Obaid S. Shaikh,Holly Tillman,Nahid Attar,Robert H. Purcell,William M. Lee +8 more
TL;DR: Past exposure to HEV with detectable anti‐HEV IgG was significantly more common in the ALF patients compared to the general U.S. population and could not be implicated in any indeterminate, autoimmune, or pregnancy‐related ALF cases.
References
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Journal ArticleDOI
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
TL;DR: In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.
Journal ArticleDOI
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Journal ArticleDOI
A novel virus in swine is closely related to the human hepatitis E virus
Xiang-Jin Meng,Robert H. Purcell,Patrick G. Halbur,James R. Lehman,Dale M. Webb,Tatiana S. Tsareva,Joseph S. Haynes,Brad J. Thacker,Suzanne U. Emerson +8 more
TL;DR: The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs.
Journal ArticleDOI
Hepatitis E virus.
TL;DR: Hepatitis E virus is an enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis in many countries of Asia and Africa but only rarely causes disease in more industrialised countries.
Journal ArticleDOI
Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States
Naga Chalasani,Robert J. Fontana,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Paul B. Watkins,Timothy J. Davern,Jose Serrano,Hongqiu Yang,James Rochon +9 more
TL;DR: This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled in a prospective study to recruit patients with suspected idiosyncratic drug-induced liver injury and create a repository of biological samples for analysis.
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