An Epigenetic Signature for Monoallelic Olfactory Receptor Expression
Angeliki Magklara,Angela Yen,Angela Yen,Bradley M. Colquitt,E. Josephine Clowney,William E. Allen,Eirene Markenscoff-Papadimitriou,Zoe A. Evans,Pouya Kheradpour,Pouya Kheradpour,George Mountoufaris,Catriona Carey,Gilad Barnea,Manolis Kellis,Manolis Kellis,Stavros Lomvardas +15 more
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TLDR
The data suggest that OR silencing takes place before OR expression, indicating that it is not the product of an OR-elicited feedback signal, and suggests that chromatin-mediated silencing lays a molecular foundation upon which singular and stochastic selection for gene expression can be applied.About:
This article is published in Cell.The article was published on 2011-05-13 and is currently open access. It has received 273 citations till now. The article focuses on the topics: Constitutive heterochromatin & Heterochromatin.read more
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Global Epigenomic Reconfiguration During Mammalian Brain Development
Ryan Lister,Ryan Lister,Eran A. Mukamel,Joseph R. Nery,Mark A. Urich,Clare A. Puddifoot,Nicholas D. Johnson,Jacinta Lucero,Yun Huang,Andrew J. Dwork,Matthew D. Schultz,Matthew D. Schultz,Miao Yu,Julian Tonti-Filippini,Holger Heyn,Shijun Hu,Joseph C. Wu,Anjana Rao,Manel Esteller,Chuan He,Fatemeh Haghighi,Terrence J. Sejnowski,Terrence J. Sejnowski,M. Margarita Behrens,Joseph R. Ecker +24 more
TL;DR: The results extend the knowledge of the unique role of DNA methylation in brain development and function, and offer a new framework for testing the role of the epigenome in healthy function and in pathological disruptions of neural circuits.
Journal ArticleDOI
Parental olfactory experience influences behavior and neural structure in subsequent generations
Brian G. Dias,Kerry J. Ressler +1 more
TL;DR: Using olfactory molecular specificity, the inheritance of parental traumatic exposure is examined and a framework for addressing how environmental information may be inherited transgenerationally at behavioral, neuroanatomical and epigenetic levels is provided.
Journal ArticleDOI
Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues
Jiang Zhu,Mazhar Adli,James Zou,Griet Verstappen,Griet Verstappen,Michael Coyne,Xiaolan Zhang,Timothy Durham,Mohammad Miri,Vikram Deshpande,Philip L. De Jager,Philip L. De Jager,David A. Bennett,Joseph A. Houmard,Deborah M. Muoio,Tamer T. Onder,Raymond Camahort,Raymond Camahort,Chad A. Cowan,Chad A. Cowan,Alexander Meissner,Alexander Meissner,Charles B. Epstein,Noam Shoresh,Bradley E. Bernstein +24 more
TL;DR: The chromatin genome-wide in a large and diverse collection of human tissues and stem cells is mapped to yield unprecedented annotations of functional genomic elements and their regulation across developmental stages, lineages, and cellular environments.
Journal ArticleDOI
Dynamic regulation of transcriptional states by chromatin and transcription factors
Ty C. Voss,Gordon L. Hager +1 more
TL;DR: This Review discusses emerging concepts regarding the function of regulatory elements in living cells and the involvement of these dynamic and stochastic processes in the evolution of fluctuating transcriptional activity states that are now commonly reported in eukaryotic systems.
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Dynamics and Memory of Heterochromatin in Living Cells
Nathaniel A. Hathaway,Oliver Bell,Courtney Hodges,Erik L. Miller,Dana S. Neel,Gerald R. Crabtree +5 more
TL;DR: A chromatin in vivo assay (CiA) system employing chemically induced proximity to initiate and terminate chromatin modifications in living cells and quantitative modeling of reaction kinetics revealed that dynamic competition between histone marking and turnover, determines the boundaries and stability of H3K9me3 domains.
References
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A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
Linda B. Buck,Richard Axel +1 more
TL;DR: This work has cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium and is likely to encode a diverse family of odorant receptors.
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A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells
TL;DR: The results of a genome-wide analysis of human cells suggest that most protein-coding genes, including most genes thought to be transcriptionally inactive, experience transcription initiation, and that transcription initiation at most genes is a general phenomenon in human cells.
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