scispace - formally typeset
Open AccessJournal ArticleDOI

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources.

Reads0
Chats0
TLDR
BioGPS http://biogps.gnf.org is introduced, a centralized gene portal for aggregating distributed gene annotation resources, and embraces the principle of community intelligence, enabling any user to easily and directly contribute to the BioGPS platform.
Abstract
Online gene annotation resources are indispensable for analysis of genomics data. However, the landscape of these online resources is highly fragmented, and scientists often visit dozens of these sites for each gene in a candidate gene list. Here, we introduce BioGPS http://biogps.gnf.org, a centralized gene portal for aggregating distributed gene annotation resources. Moreover, BioGPS embraces the principle of community intelligence, enabling any user to easily and directly contribute to the BioGPS platform.

read more

Content maybe subject to copyright    Report

Citations
More filters
Journal ArticleDOI

Molecular insight into the regulation and function of MCAK

TL;DR: Recently published data concerning MCAK are summarized, its conformation changes with its depolymerization activity and function are correlated, a model of its regulation by multiple mitotic kinases is proposed and its potential involvement in oncogenesis and drug resistance is highlighted.
Journal ArticleDOI

Gasdermin Family: a Promising Therapeutic Target for Stroke

TL;DR: The biological characteristic of GSDM family and their possible roles in stroke-induced brain injury are discussed, and it is hypothesize the feasibility of using GSDMs as a potential target for stroke treatment.
Journal ArticleDOI

Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes.

TL;DR: The ease of visualizing data on these maps was demonstrated by using published microarray data from human hepatocyte-like cell models, exemplifying - where a sufficient capacity for metabolizing chemicals is a prerequisite for a suited model - how the biotransformation pathway maps can be used for model selection.
Journal ArticleDOI

Novel Common Integration Sites Targeted by Mouse Mammary Tumor Virus Insertion in Mammary Tumors Have Oncogenic Activity

TL;DR: It is shown here that expression of these three putative oncogenes in normal murine mammary gland cells altered their growth kinetics and caused their morphological transformation when grown in three dimensional cultures.
Journal ArticleDOI

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development

TL;DR: It is proposed that a better understanding of placenta-enriched molecules biology, and potential contribution to the pathogenesis of diseases, may yield more predictive diagnostic and therapeutic targets.
References
More filters
Journal ArticleDOI

Most mammalian mRNAs are conserved targets of microRNAs

TL;DR: This work overhauled its tool for finding preferential conservation of sequence motifs and applied it to the analysis of human 3'UTRs, increasing by nearly threefold the detected number of preferentially conserved miRNA target sites.
Journal ArticleDOI

KEGG for linking genomes to life and the environment

TL;DR: KEGG PATHWAY is now supplemented with a new global map of metabolic pathways, which is essentially a combined map of about 120 existing pathway maps, and the KEGG resource is being expanded to suit the needs for practical applications.
Journal ArticleDOI

Genome-wide atlas of gene expression in the adult mouse brain

Ed S. Lein, +109 more
- 11 Jan 2007 - 
TL;DR: An anatomically comprehensive digital atlas containing the expression patterns of ∼20,000 genes in the adult mouse brain is described, providing an open, primary data resource for a wide variety of further studies concerning brain organization and function.
Journal ArticleDOI

A gene atlas of the mouse and human protein-encoding transcriptomes

TL;DR: In this paper, high-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a genome scale, and the authors have designed custom arrays that interrogate the expression of the vast majority of proteinencoding human and mouse genes and have used them to profile a panel of 79 human and 61 mouse tissues.
Journal ArticleDOI

STRING 8—a global view on proteins and their functional interactions in 630 organisms

TL;DR: The most important new developments in STRING 8 over previous releases include a URL-based programming interface, improved interaction prediction via genomic neighborhood in prokaryotes, and the inclusion of protein structures.
Related Papers (5)