BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources.
Chunlei Wu,Camilo Orozco,Jason Boyer,Marc Leglise,James Goodale,Serge Batalov,Christopher L Hodge,James Haase,Jeff Janes,Jon W. Huss,Andrew I. Su +10 more
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TLDR
BioGPS http://biogps.gnf.org is introduced, a centralized gene portal for aggregating distributed gene annotation resources, and embraces the principle of community intelligence, enabling any user to easily and directly contribute to the BioGPS platform.Abstract:
Online gene annotation resources are indispensable for analysis of genomics data. However, the landscape of these online resources is highly fragmented, and scientists often visit dozens of these sites for each gene in a candidate gene list. Here, we introduce BioGPS http://biogps.gnf.org, a centralized gene portal for aggregating distributed gene annotation resources. Moreover, BioGPS embraces the principle of community intelligence, enabling any user to easily and directly contribute to the BioGPS platform.read more
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hCD2-iCre and Vav-iCre Mediated Gene Recombination Patterns in Murine Hematopoietic Cells
TL;DR: The results confirm the known activity patterns for both Cre transgenes and unveil additional hCD2-iCre mediated reporter gene recombination in common lymphoid progenitors, in natural killer cells and their progenitor, and in plasmacytoid and conventional dendritic cells.
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Local M-CSF (Macrophage Colony-Stimulating Factor) Expression Regulates Macrophage Proliferation and Apoptosis in Atherosclerosis.
Satyesh K. Sinha,Aika Miikeda,Zachary Fouladian,Margarete Mehrabian,Chantle Edillor,Diana M. Shih,Zhiqiang Zhou,Manash K. Paul,Sarada Charugundla,Richard C. Davis,Tripathi B. Rajavashisth,Aldons J. Lusis +11 more
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A systematic characterization of genes underlying both complex and Mendelian diseases
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A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome
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The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.
Wilson Castro,Sonia T. Chelbi,Sonia T. Chelbi,Charlène Niogret,Cristina Ramon-Barros,Suzanne P. M. Welten,Kevin Osterheld,Haiping Wang,Giorgia Rota,Leonor Morgado,Eric Vivier,Miro E. Raeber,Onur Boyman,Mauro Delorenzi,Mauro Delorenzi,David Barras,Ping-Chih Ho,Annette Oxenius,Greta Guarda,Greta Guarda +19 more
TL;DR: It is found that deletion of Rfx7 leads to a decrease in natural killer cell maintenance and immunity in vivo, and RFX7 emerges as a novel transcriptional regulator of NK cell homeostasis and metabolic quiescence.
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Journal ArticleDOI
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Andrew I. Su,Tim Wiltshire,Serge Batalov,Hilmar Lapp,Keith A. Ching,David Block,Jie Zhang,Richard Soden,Mimi Hayakawa,Gabriel Kreiman,Gabriel Kreiman,Michael P. Cooke,John R. Walker,John B. Hogenesch,John B. Hogenesch +14 more
TL;DR: In this paper, high-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a genome scale, and the authors have designed custom arrays that interrogate the expression of the vast majority of proteinencoding human and mouse genes and have used them to profile a panel of 79 human and 61 mouse tissues.
Journal ArticleDOI
STRING 8—a global view on proteins and their functional interactions in 630 organisms
Lars Juhl Jensen,Michael Kuhn,Manuel Stark,Samuel Chaffron,Christopher J. Creevey,Jean Muller,T. Doerks,Philippe Julien,Alexander Roth,Milan Simonovic,Peer Bork,Christian von Mering +11 more
TL;DR: The most important new developments in STRING 8 over previous releases include a URL-based programming interface, improved interaction prediction via genomic neighborhood in prokaryotes, and the inclusion of protein structures.
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