Journal ArticleDOI
Bone marrow as a potential source of hepatic oval cells.
Bryon E. Petersen,W. C. Bowen,K. D. Patrene,Wendy M. Mars,A. K. Sullivan,N. Murase,S. S. Boggs,Joel S. Greenberger,Julie P. Goff +8 more
TLDR
A stem cell associated with the bone marrow has epithelial cell lineage capability and a proportion of the regenerated hepatic cells were shown to be donor-derived.Abstract:
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.read more
Citations
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Journal ArticleDOI
Liver-specific gene expression in cultured human hematopoietic stem cells.
Henning C. Fiegel,Michael Lioznov,Lourdes Cortes-Dericks,Claudia Lange,Dietrich Kluth,Boris Fehse,Axel R. Zander +6 more
TL;DR: The results indicate that CD34+ adult human bone marrow stem cells can differentiate into hepatocytic cells in vitro.
Book ChapterDOI
Mesenchymal stem cells increase self-renewal of small intestinal epithelium and accelerate structural recovery after radiation injury.
A. Semont,Sabine François,Moubarak Mouiseddine,Agnès François,A. Sache,Johanna Frick,Dominique Thierry,Alain Chapel +7 more
TL;DR: This work supports, the use of MSC infusion to repair damaged GI tract in patients subjected to radiotherapy by showing a structural recovery accompanied by an increase of small intestinal villus height, three and fifteen days following abdominal radiation exposure.
Engrafted bone marrow-derived FIK-1^+ mesenchymal stem cells regenerate skin tissue
TL;DR: Findings provide direct evidence that bone marrow-derived cells can give rise to functional skin cells and regenerate skin tissue and may have important scientific implications in stem cell biology and transplantation therapy for skin tissue injury.
Journal ArticleDOI
Inducible differentiation and morphogenesis of bipotential liver cell lines from wild-type mouse embryos
TL;DR: It is shown that hepatic cell lines reproducibly can be derived from E14 embryos of many mouse inbred strains, and the establishment of a simple and reproducible method to isolate from any mouse embryo bipotential liver cell lines that exhibit the properties of transit stem cells provides a novel paradigm for investigation of hepaticcell lineage relationships.
Journal ArticleDOI
Bone Marrow Progenitors Are Not the Source of Expanding Oval Cells in Injured Liver
Anuradha Menthena,Niloyjyoti Deb,Michael Oertel,Petar N. Grozdanov,Jaswinder Sandhu,Shalin J. Shah,Chandan Guha,David A. Shafritz,Mariana D. Dabeva +8 more
TL;DR: The data demonstrate that the sources of oval cells and small hepatocytes in the injured liver are endogenous liver progenitors and that they do not arise through transdifferentiation from BM cells.
References
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Journal ArticleDOI
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Giuliana Ferrari,Gabriella Cusella,Gabriella Cusella,D. De Angelis,D. De Angelis,M. Coletta,M. Coletta,Egle Paolucci,Egle Paolucci,Anna Stornaiuolo,Anna Stornaiuolo,Giulio Cossu,Giulio Cossu,Fulvio Mavilio,Fulvio Mavilio +14 more
TL;DR: Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers.
Journal Article
In vivo differentiation of rat liver oval cells into hepatocytes.
Ritva P. Evarts,Peter Nagy,Harushige Nakatsukasa,Elizabeth R. Marsden,Snorri S. Thorgeirsson +4 more
TL;DR: The data indicate that oval cells can differentiate to hepatocytes and may have an important physiological function as a source of major serum proteins when hepatocytes are unable to synthesize these proteins.
Journal ArticleDOI
Presence of hematopoietic stem cells in the adult liver
TL;DR: The data obtained from the mouse study strongly suggest that hematopoietic stem cells residing in the donor liver are responsible for mixed chimerism and maintenance of tolerance after liver transplantation.
Journal Article
Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.
TL;DR: The SCF/c-kit system may, possibly in combination with other growth factor/receptor systems, be involved in the early activation of the hepatic stem cells as well as in the expansion and differentiation of oval cells.
Journal ArticleDOI
Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to brown Norway rats.
Noriko Murase,Thomas E. Starzl,Minoru Tanabe,Shigeru Fujisaki,H. Miyazawa,Qing Ye,Conor P. Delaney,John J. Fung,Anthony J. Demetris +8 more
TL;DR: Both the GVHD propensity and tolerogenicity in these experiments were closely associated with recipient tissue chimerism 30 and 100 days after the experiments began, and these observations provide guidelines that should be considered in devising leukocyte augmentation protocols for human whole organ recipients.