Journal ArticleDOI
Bone marrow as a potential source of hepatic oval cells.
Bryon E. Petersen,W. C. Bowen,K. D. Patrene,Wendy M. Mars,A. K. Sullivan,N. Murase,S. S. Boggs,Joel S. Greenberger,Julie P. Goff +8 more
TLDR
A stem cell associated with the bone marrow has epithelial cell lineage capability and a proportion of the regenerated hepatic cells were shown to be donor-derived.Abstract:
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.read more
Citations
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Journal ArticleDOI
Fetal microchimerism alone does not contribute to the induction of primary biliary cirrhosis
Atsushi Tanaka,Atsushi Tanaka,Keith D. Lindor,Robert G. Gish,Kenneth P. Batts,Yasushi Shiratori,Masao Omata,J. Lee Nelson,Aftab A. Ansari,Ross L. Coppel,Margaret Newsome,M. Eric Gershwin +11 more
TL;DR: Results, using the more sensitive technology, showed that microchimerism is a very common event in human liver and supported the thesis that this may contribute to the induction/maintenance of fetal tolerance.
Journal ArticleDOI
Evidence for epithelial-mesenchymal transitions in adult liver cells
Jason K. Sicklick,Steve S. Choi,Marcia Bustamante,Shannon J. McCall,Elizabeth Hernandez Perez,Jiawen Huang,Yin-Xiong Li,Marcos Rojkind,Anna Mae Diehl +8 more
TL;DR: HSC and hepatic epithelial progenitors both coexpress epithelial and mesenchymal markers, providing evidence that EMT occurs in adult liver cells.
Journal ArticleDOI
Stem cells in liver regeneration and therapy.
TL;DR: Although much more has to be learned about the role of stem/progenitor cells in the physiology and pathophysiology of the liver, experimental analysis of the therapeutic value of these cells has been initiated and transplants or in vivo pharmacological activation of the pool of hepatic stem cells may provide novel modalities for the therapy of liver diseases.
Journal ArticleDOI
Plasticity of bone marrow-derived stem cells
TL;DR: A review of the literature that lends credibility to the theory that highly plastic BMCs have a role in maintenance and repair of nonhematopoietic tissue is presented in this article.
Journal ArticleDOI
Hepatic progenitor cells in human fetal liver express the oval cell marker Thy-1
TL;DR: Data suggest that Thy-1 is a marker of liver stem cells in human fetal liver, as indicated by coexpression of biliary and hepatocellular proteins and mRNA.
References
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Journal ArticleDOI
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Giuliana Ferrari,Gabriella Cusella,Gabriella Cusella,D. De Angelis,D. De Angelis,M. Coletta,M. Coletta,Egle Paolucci,Egle Paolucci,Anna Stornaiuolo,Anna Stornaiuolo,Giulio Cossu,Giulio Cossu,Fulvio Mavilio,Fulvio Mavilio +14 more
TL;DR: Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers.
Journal Article
In vivo differentiation of rat liver oval cells into hepatocytes.
Ritva P. Evarts,Peter Nagy,Harushige Nakatsukasa,Elizabeth R. Marsden,Snorri S. Thorgeirsson +4 more
TL;DR: The data indicate that oval cells can differentiate to hepatocytes and may have an important physiological function as a source of major serum proteins when hepatocytes are unable to synthesize these proteins.
Journal ArticleDOI
Presence of hematopoietic stem cells in the adult liver
TL;DR: The data obtained from the mouse study strongly suggest that hematopoietic stem cells residing in the donor liver are responsible for mixed chimerism and maintenance of tolerance after liver transplantation.
Journal Article
Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.
TL;DR: The SCF/c-kit system may, possibly in combination with other growth factor/receptor systems, be involved in the early activation of the hepatic stem cells as well as in the expansion and differentiation of oval cells.
Journal ArticleDOI
Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to brown Norway rats.
Noriko Murase,Thomas E. Starzl,Minoru Tanabe,Shigeru Fujisaki,H. Miyazawa,Qing Ye,Conor P. Delaney,John J. Fung,Anthony J. Demetris +8 more
TL;DR: Both the GVHD propensity and tolerogenicity in these experiments were closely associated with recipient tissue chimerism 30 and 100 days after the experiments began, and these observations provide guidelines that should be considered in devising leukocyte augmentation protocols for human whole organ recipients.