Journal ArticleDOI
Bone marrow as a potential source of hepatic oval cells.
Bryon E. Petersen,W. C. Bowen,K. D. Patrene,Wendy M. Mars,A. K. Sullivan,N. Murase,S. S. Boggs,Joel S. Greenberger,Julie P. Goff +8 more
TLDR
A stem cell associated with the bone marrow has epithelial cell lineage capability and a proportion of the regenerated hepatic cells were shown to be donor-derived.Abstract:
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.read more
Citations
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Analyses to clarify rich fractions in hepatic progenitor cells from human umbilical cord blood and cell fusion
Yoshitada Tanabe,Fumihito Tajima,Yuki Nakamura,Eriko Shibasaki,Mai Wakejima,Takashi Shimomura,Rie Murai,Y. Murawaki,Koichi Hashiguchi,Takamasa Kanbe,Toshiya Saeki,Miho Ichiba,Yoko Yoshida,Masahiro Mitsunari,Soichi Yoshida,Junichiro Miake,Yasutaka Yamamoto,Naoki Nagata,Tasuku Harada,Akihiro Kurimasa,Ichiro Hisatome,Naoki Terakawa,Yoshikazu Murawaki,Goshi Shiota +23 more
TL;DR: It is suggested that CD34+UCB cells are rich fractions in hepatic progenitor cells, and that transdifferentiation from UCB cells into hepatocytes as well as cell fusion simultaneously occur in this situation.
Journal ArticleDOI
Stromal cells retard the differentiation of CD34+CD38low/neg human primitive progenitors exposed to cytokines independent of their mitotic history
Annelise Bennaceur-Griscelli,Corinne Pondarré,Valérie Schiavon,William Vainchenker,Laure Coulombel +4 more
TL;DR: The results indicate that cytokines and stroma-derived signals can regulate independently the proliferation and differentiation of primitive cells and that these strome-derived extracellular factors act directly on their target cells.
Journal ArticleDOI
Adult bone marrow-derived stem cells for the lung: implications for pediatric lung diseases.
TL;DR: This article critically reviews the current advances on the therapeutic use of stem cells for lung regeneration and suggests that BMSC can engraft and differentiate into a variety of lung cells, but these findings have been challenged recently.
Journal ArticleDOI
Mobilization of CD34+ hematopoietic cells, colony-forming cells and long-term culture-initiating cells into the peripheral blood of patients with an acute cerebral ischemic insult.
Burkhard Hennemann,Guntram W. Ickenstein,Sophie Sauerbruch,K. Luecke,S. Haas,Markus Horn,Reinhard Andreesen,Ulrich Bogdahn,Jürgen Winkler +8 more
TL;DR: The results showed a recruitment of hematopoietic progenitor cells from the BM into the peripheral blood after acute ischemic stroke when no thrombolytic treatment was given.
Journal ArticleDOI
Bone marrow-derived mesenchymal stem cell therapy for decompensated liver cirrhosis: a meta-analysis.
TL;DR: Bone marrow-derived mesenchymal stem cell therapy for decompensated liver cirrhosis: A meta-analysis as discussed by the authors was the first attempt to use stem cells for liver transplant.
References
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Journal ArticleDOI
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Giuliana Ferrari,Gabriella Cusella,Gabriella Cusella,D. De Angelis,D. De Angelis,M. Coletta,M. Coletta,Egle Paolucci,Egle Paolucci,Anna Stornaiuolo,Anna Stornaiuolo,Giulio Cossu,Giulio Cossu,Fulvio Mavilio,Fulvio Mavilio +14 more
TL;DR: Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers.
Journal Article
In vivo differentiation of rat liver oval cells into hepatocytes.
Ritva P. Evarts,Peter Nagy,Harushige Nakatsukasa,Elizabeth R. Marsden,Snorri S. Thorgeirsson +4 more
TL;DR: The data indicate that oval cells can differentiate to hepatocytes and may have an important physiological function as a source of major serum proteins when hepatocytes are unable to synthesize these proteins.
Journal ArticleDOI
Presence of hematopoietic stem cells in the adult liver
TL;DR: The data obtained from the mouse study strongly suggest that hematopoietic stem cells residing in the donor liver are responsible for mixed chimerism and maintenance of tolerance after liver transplantation.
Journal Article
Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.
TL;DR: The SCF/c-kit system may, possibly in combination with other growth factor/receptor systems, be involved in the early activation of the hepatic stem cells as well as in the expansion and differentiation of oval cells.
Journal ArticleDOI
Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to brown Norway rats.
Noriko Murase,Thomas E. Starzl,Minoru Tanabe,Shigeru Fujisaki,H. Miyazawa,Qing Ye,Conor P. Delaney,John J. Fung,Anthony J. Demetris +8 more
TL;DR: Both the GVHD propensity and tolerogenicity in these experiments were closely associated with recipient tissue chimerism 30 and 100 days after the experiments began, and these observations provide guidelines that should be considered in devising leukocyte augmentation protocols for human whole organ recipients.