Journal ArticleDOI
Bone marrow as a potential source of hepatic oval cells.
Bryon E. Petersen,W. C. Bowen,K. D. Patrene,Wendy M. Mars,A. K. Sullivan,N. Murase,S. S. Boggs,Joel S. Greenberger,Julie P. Goff +8 more
TLDR
A stem cell associated with the bone marrow has epithelial cell lineage capability and a proportion of the regenerated hepatic cells were shown to be donor-derived.Abstract:
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.read more
Citations
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Patent
Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
Henry E. Young,Paul A. Lucas +1 more
TL;DR: In this article, a method for transplanting the pluripotent stem cells of the present invention in a mammalian host, such as human, comprising introducing the stem cells, into the host.
Journal ArticleDOI
Stem cell bioprocessing: fundamentals and principles.
Mark R Placzek,I-Ming Chung,Hugo Macedo,Siti Norhayati Ismail,Teresa Mortera Blanco,Mayasari Lim,Jae Min Cha,Iliana Fauzi,Yunyi Kang,David C. Yeo,Chi Yip Joan Ma,Julia M. Polak,Nicki Panoskaltsis,Athanasios Mantalaris +13 more
TL;DR: This review aims to address the principles required for successful stem cell bioprocessing so that they can be applied deftly to clinical applications.
Journal ArticleDOI
Hematopoietic development: a balancing act.
Alan B. Cantor,Stuart H. Orkin +1 more
TL;DR: Evidence has emerged demonstrating that cross-antagonism of lineage-specific transcription factors plays an important role in determining cell phenotype by actively repressing alternate lineage gene programs.
Journal ArticleDOI
Enhancement of neuroplasticity through upregulation of β1-integrin in human umbilical cord-derived stromal cell implanted stroke model
Dah-Ching Ding,Woei Cherng Shyu,Ming Fu Chiang,Shinn Zong Lin,Ying Chen Chang,Hsiao Jung Wang,Ching Yuan Su,Hung Li +7 more
TL;DR: Modulation by stem cell-derived macrophage/microglial interactions, and increased beta1-integrin expression, might enhance this angiogenic architecture within the ischemic brain.
Journal ArticleDOI
Present status and perspectives of cell-based therapies for liver diseases
Andreas K. Nussler,Sarah König,Michael Ott,Etienne Sokal,Bruno Christ,Wolfgang E. Thasler,Marc Brulport,Geredn Gabelein,Wiebke Schormann,Maren Schulze,Ewa Ellis,Matthias Kraemer,Frank Nocken,Wolfgang E. Fleig,Michael Manns,Steven C. Strom,Jan G. Hengstler +16 more
TL;DR: The present status of cell based therapies for liver diseases and the possible role of stem cells in liver tissue repair are summarized to identify areas of future preclinical and clinical research.
References
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Journal ArticleDOI
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Giuliana Ferrari,Gabriella Cusella,Gabriella Cusella,D. De Angelis,D. De Angelis,M. Coletta,M. Coletta,Egle Paolucci,Egle Paolucci,Anna Stornaiuolo,Anna Stornaiuolo,Giulio Cossu,Giulio Cossu,Fulvio Mavilio,Fulvio Mavilio +14 more
TL;DR: Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers.
Journal Article
In vivo differentiation of rat liver oval cells into hepatocytes.
Ritva P. Evarts,Peter Nagy,Harushige Nakatsukasa,Elizabeth R. Marsden,Snorri S. Thorgeirsson +4 more
TL;DR: The data indicate that oval cells can differentiate to hepatocytes and may have an important physiological function as a source of major serum proteins when hepatocytes are unable to synthesize these proteins.
Journal ArticleDOI
Presence of hematopoietic stem cells in the adult liver
TL;DR: The data obtained from the mouse study strongly suggest that hematopoietic stem cells residing in the donor liver are responsible for mixed chimerism and maintenance of tolerance after liver transplantation.
Journal Article
Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.
TL;DR: The SCF/c-kit system may, possibly in combination with other growth factor/receptor systems, be involved in the early activation of the hepatic stem cells as well as in the expansion and differentiation of oval cells.
Journal ArticleDOI
Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to brown Norway rats.
Noriko Murase,Thomas E. Starzl,Minoru Tanabe,Shigeru Fujisaki,H. Miyazawa,Qing Ye,Conor P. Delaney,John J. Fung,Anthony J. Demetris +8 more
TL;DR: Both the GVHD propensity and tolerogenicity in these experiments were closely associated with recipient tissue chimerism 30 and 100 days after the experiments began, and these observations provide guidelines that should be considered in devising leukocyte augmentation protocols for human whole organ recipients.