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Journal ArticleDOI

Bone marrow as a potential source of hepatic oval cells.

TLDR
A stem cell associated with the bone marrow has epithelial cell lineage capability and a proportion of the regenerated hepatic cells were shown to be donor-derived.
Abstract:Ā 
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.

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Journal ArticleDOI

The thin red line: Angiogenesis in normal and malignant hematopoiesis

TL;DR: This review describes the current knowledge about cell subsets involved in vasculogenesis and angiogenesis, together with recent findings about angiogenic and antiangiogenic therapies in hematopoietic malignancies such as leukemia, lymphoma, myeloma, and myelodysplastic syndromes.
Journal ArticleDOI

Capturing the Promise of Youth

Gretchen Vogel
- 17 DecĀ 1999Ā -Ā 
TL;DR: This work, which raises hopes of dazzling medical applications and also forces scientists to reconsider fundamental ideas about how cells grow up, is hailed as 19999s Breakthrough of the Year.
Journal ArticleDOI

Muse Cells Provide the Pluripotency of Mesenchymal Stem Cells: Direct Contribution of Muse Cells to Tissue Regeneration:

TL;DR: Muse cells are particularly unique compared with other stem cells in that they efficiently migrate and integrate into damaged tissue when supplied into the bloodstream, and spontaneously differentiate into cells compatible with the homing tissue.
Journal ArticleDOI

Liver cancer stem cells: implications for a new therapeutic target

TL;DR: The origin of liver stem cells and its relation to HCC development are discussed and the current CSC markers in HCC are summarized to discuss their relevance to the treatment of this deadly disease.
Journal ArticleDOI

Adult neural stem cells, neurogenic niches, and cellular therapy.

TL;DR: It is hypothesized that neurogenic niches underlie the properties and functions of NSCs in the adult central nervous system and may hold the key to the understanding of neurogenesis in theAdult brain.
References
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Journal ArticleDOI

Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors

TL;DR: Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers.
Journal Article

In vivo differentiation of rat liver oval cells into hepatocytes.

TL;DR: The data indicate that oval cells can differentiate to hepatocytes and may have an important physiological function as a source of major serum proteins when hepatocytes are unable to synthesize these proteins.
Journal ArticleDOI

Presence of hematopoietic stem cells in the adult liver

TL;DR: The data obtained from the mouse study strongly suggest that hematopoietic stem cells residing in the donor liver are responsible for mixed chimerism and maintenance of tolerance after liver transplantation.
Journal Article

Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.

TL;DR: The SCF/c-kit system may, possibly in combination with other growth factor/receptor systems, be involved in the early activation of the hepatic stem cells as well as in the expansion and differentiation of oval cells.
Journal ArticleDOI

Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to brown Norway rats.

TL;DR: Both the GVHD propensity and tolerogenicity in these experiments were closely associated with recipient tissue chimerism 30 and 100 days after the experiments began, and these observations provide guidelines that should be considered in devising leukocyte augmentation protocols for human whole organ recipients.
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