Journal ArticleDOI
Bone marrow as a potential source of hepatic oval cells.
Bryon E. Petersen,W. C. Bowen,K. D. Patrene,Wendy M. Mars,A. K. Sullivan,N. Murase,S. S. Boggs,Joel S. Greenberger,Julie P. Goff +8 more
TLDR
A stem cell associated with the bone marrow has epithelial cell lineage capability and a proportion of the regenerated hepatic cells were shown to be donor-derived.Abstract:
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.read more
Citations
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Journal ArticleDOI
Autologous Bone Marrow Infusion Activates the Progenitor Cell Compartment in Patients with Advanced Liver Cirrhosis
Ja Kyung Kim,Young Nyun Park,Jin Seok Kim,Mi-Suk Park,Yong Han Paik,Jae Yeon Seok,Yong Eun Chung,Hyun Ok Kim,Kyung Sik Kim,Sang Hoon Ahn,Do Young Kim,Myeong-Jin Kim,Kwan Sik Lee,Chae Yoon Chon,Soo Jeong Kim,Shuji Terai,Isao Sakaida,Kwang Hyub Han +17 more
TL;DR: Although clinical improvement was sustained for more than 6 months, histological changes in the liver returned to baseline 6 months after ABMI, further comparative studies are warranted.
Journal ArticleDOI
Bone marrow-derived stem cells and radiation response.
TL;DR: The status of research in the areas of stem cell quiescence, niche contact, and migratory responses to ionizing irradiation is defined.
Journal ArticleDOI
Therapeutic Potential of Adipose-Derived SSEA-3-Positive Muse Cells for Treating Diabetic Skin Ulcers
Kahori Kinoshita,Shinichiro Kuno,Hisako Ishimine,Noriyuki Aoi,Kazuhide Mineda,Harunosuke Kato,Kentaro Doi,Koji Kanayama,Jingwei Feng,Takanobu Mashiko,Akira Kurisaki,Kotaro Yoshimura +11 more
TL;DR: The selected population of ASCs has greater therapeutic effects to accelerate impaired wound healing associated with type 1 diabetes and could be a practical tool for a variety of stem cell‐depleted or ischemic conditions of various organs and tissues.
Journal ArticleDOI
Progenitor and stem cells for bone and cartilage regeneration.
M. K. El Tamer,Rui L. Reis +1 more
TL;DR: The present review gives a comprehensive overview of the developments in stem cells originating from different tissues and suggests future prospects for functional bone and cartilage tissue regeneration.
Journal ArticleDOI
Fetal and adult liver stem cells for liver regeneration and tissue engineering.
Henning C. Fiegel,Claudia Lange,Ulrich Kneser,Wolfgang Lambrecht,A.R. Zander,Xavier Rogiers,Dietrich Kluth +6 more
TL;DR: Different types of fetal liver (stem) cells during development were identified, and their advantageous growth potential and bipotential differentiation capacity were shown, however, ethical and legal issues have to be addressed before using fetal cells.
References
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Journal ArticleDOI
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Giuliana Ferrari,Gabriella Cusella,Gabriella Cusella,D. De Angelis,D. De Angelis,M. Coletta,M. Coletta,Egle Paolucci,Egle Paolucci,Anna Stornaiuolo,Anna Stornaiuolo,Giulio Cossu,Giulio Cossu,Fulvio Mavilio,Fulvio Mavilio +14 more
TL;DR: Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers.
Journal Article
In vivo differentiation of rat liver oval cells into hepatocytes.
Ritva P. Evarts,Peter Nagy,Harushige Nakatsukasa,Elizabeth R. Marsden,Snorri S. Thorgeirsson +4 more
TL;DR: The data indicate that oval cells can differentiate to hepatocytes and may have an important physiological function as a source of major serum proteins when hepatocytes are unable to synthesize these proteins.
Journal ArticleDOI
Presence of hematopoietic stem cells in the adult liver
TL;DR: The data obtained from the mouse study strongly suggest that hematopoietic stem cells residing in the donor liver are responsible for mixed chimerism and maintenance of tolerance after liver transplantation.
Journal Article
Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.
TL;DR: The SCF/c-kit system may, possibly in combination with other growth factor/receptor systems, be involved in the early activation of the hepatic stem cells as well as in the expansion and differentiation of oval cells.
Journal ArticleDOI
Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to brown Norway rats.
Noriko Murase,Thomas E. Starzl,Minoru Tanabe,Shigeru Fujisaki,H. Miyazawa,Qing Ye,Conor P. Delaney,John J. Fung,Anthony J. Demetris +8 more
TL;DR: Both the GVHD propensity and tolerogenicity in these experiments were closely associated with recipient tissue chimerism 30 and 100 days after the experiments began, and these observations provide guidelines that should be considered in devising leukocyte augmentation protocols for human whole organ recipients.