Journal ArticleDOI
Bone marrow as a potential source of hepatic oval cells.
Bryon E. Petersen,W. C. Bowen,K. D. Patrene,Wendy M. Mars,A. K. Sullivan,N. Murase,S. S. Boggs,Joel S. Greenberger,Julie P. Goff +8 more
TLDR
A stem cell associated with the bone marrow has epithelial cell lineage capability and a proportion of the regenerated hepatic cells were shown to be donor-derived.Abstract:
Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.read more
Citations
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Treatment of inflammatory diseases with mesenchymal stem cells.
TL;DR: Human mesenchymal stem cells are rare progenitor cells present in adult bone marrow that have the capacity to differentiate into a variety of tissue types, including bone, cartilage, tendon, fat, and muscle, providing therapeutic potential for treating diseases characterized by the presence of an inflammatory component.
Journal ArticleDOI
Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats
M. B. Herrera,Valentina Fonsato,Stefano Gatti,Maria Chiara Deregibus,Andrea Sordi,Daniela Cantarella,Raffaele A. Calogero,Benedetta Bussolati,Ciro Tetta,Giovanni Camussi +9 more
TL;DR: Results suggest that MVs derived from HLSC may activate a proliferative program in remnant hepatocytes after hepatectomy by a horizontal transfer of specific mRNA subsets.
Journal ArticleDOI
A Bioartificial Liver--State of the Art
TL;DR: In these devices, patient plasma is circulated extracorporeally through a bioreactor that houses liver cells (hepatocytes) sandwiched between artificial plates or capillaries.
Journal ArticleDOI
Intraarterial Injection of Muscle-Derived Cd34+Sca-1+ Stem Cells Restores Dystrophin in mdx Mice
Yuan Torrente,Jacques P. Tremblay,Federica Pisati,Marzia Belicchi,Barbara Rossi,Manuela Sironi,F. Fortunato,Mostafa El Fahime,Maria Grazia D'Angelo,Nicolas Caron,Gabriela Constantin,Denise Paulin,Guglielmo Scarlato,Nereo Bresolin +13 more
TL;DR: It is shown that stem cell antigen 1 (Sca-1), CD34 double-positive cells purified from the muscle tissues of newborn mice are multipotent in vitro and can undergo both myogenic and multimyeloid differentiation.
Journal ArticleDOI
Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation.
Masayoshi Ohta,Yoshihisa Suzuki,Toru Noda,Yoko Ejiri,Mari Dezawa,Kazuya Kataoka,Hirotomi Chou,Namiko Ishikawa,Naoya Matsumoto,Yasushi Iwashita,Eiji Mizuta,Sadako Kuno,Chizuka Ide +12 more
TL;DR: The results suggest that BMSCs can exert effects by producing some trophic factors into the CSF or by contacting with host spinal tissues on the reduction of cavities and on the improvement of behavioral function in the rat.
References
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Journal ArticleDOI
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
Giuliana Ferrari,Gabriella Cusella,Gabriella Cusella,D. De Angelis,D. De Angelis,M. Coletta,M. Coletta,Egle Paolucci,Egle Paolucci,Anna Stornaiuolo,Anna Stornaiuolo,Giulio Cossu,Giulio Cossu,Fulvio Mavilio,Fulvio Mavilio +14 more
TL;DR: Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers.
Journal Article
In vivo differentiation of rat liver oval cells into hepatocytes.
Ritva P. Evarts,Peter Nagy,Harushige Nakatsukasa,Elizabeth R. Marsden,Snorri S. Thorgeirsson +4 more
TL;DR: The data indicate that oval cells can differentiate to hepatocytes and may have an important physiological function as a source of major serum proteins when hepatocytes are unable to synthesize these proteins.
Journal ArticleDOI
Presence of hematopoietic stem cells in the adult liver
TL;DR: The data obtained from the mouse study strongly suggest that hematopoietic stem cells residing in the donor liver are responsible for mixed chimerism and maintenance of tolerance after liver transplantation.
Journal Article
Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.
TL;DR: The SCF/c-kit system may, possibly in combination with other growth factor/receptor systems, be involved in the early activation of the hepatic stem cells as well as in the expansion and differentiation of oval cells.
Journal ArticleDOI
Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to brown Norway rats.
Noriko Murase,Thomas E. Starzl,Minoru Tanabe,Shigeru Fujisaki,H. Miyazawa,Qing Ye,Conor P. Delaney,John J. Fung,Anthony J. Demetris +8 more
TL;DR: Both the GVHD propensity and tolerogenicity in these experiments were closely associated with recipient tissue chimerism 30 and 100 days after the experiments began, and these observations provide guidelines that should be considered in devising leukocyte augmentation protocols for human whole organ recipients.