Journal ArticleDOI
Cancer-related inflammation.
TLDR
The role of cancer-associated inflammation and the particular role of MIF in malignant disease is discussed and there is evidence that the cytokine is produced by both malignant cells and infiltrating leukocytes.Citations
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Neutrophil to lymphocyte ratio (NLR) impact on the progression-free survival and overall survival of multiple myeloma patients treated with high-dose chemotherapy and autologous stem cell transplantation
D Mikulski,K; Kościelny,Mateusz Nowicki,Ewa Wawrzyniak,Marta Kalwas,Monika Kowalik,Mateusz Pryt,Emilia Sęczkowska,Agnieszka Swiatek,Agnieszka Wierzbowska,Wojciech Fendler +10 more
TL;DR: In this paper , the impact of neutrophil-to-lymphocyte ratio (NLR) and other complete blood count (CBC)-based predictors on PFS and OS of transplant-eligible multiple myeloma patients was assessed.
Journal ArticleDOI
Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer
M. Madej,Barbara Strzalka-Mrozik +1 more
TL;DR: In this article , a review summarizes knowledge about mesalazine's molecular mechanisms of action and chemopreventive effect by which it could interfere with colorectal cancer cell proliferation and survival.
Journal ArticleDOI
Dickkopf1 fuels inflammatory cytokine responses
Nikolai Jaschke,Sophie Pählig,Anupam Sinha,Timon E. Adolph,María L. Colunga,Maria Hofmann,Andrew Wang,Sylvia Thiele,Julian Schwärzler,Alexander Kleymann,Marc Gentzel,Herbert Tilg,Ben Wielockx,Lorenz C. Hofbauer,Martina Rauner,Andy Göbel,Tilman D. Rachner +16 more
TL;DR: In this paper , Dickkopf1 (DKK1) activity was found to fuel inflammatory cytokine responses in cell models, mice and humans, and genetic deletion of DKK1 but not pharmacological neutralization of soluble DKK 1 ameliorated inflammation and disease trajectories in a mouse model of endotoxemia.
Journal ArticleDOI
Nomogram Based on Hemoglobin, Albumin, Lymphocyte and Platelet Score to Predict Overall Survival in Patients with T3-4N0-1 Nasopharyngeal Carcinoma
TL;DR: In this paper , the authors used Cox proportional hazards regression analysis to generate a nomogram, which appraised by discrimination, calibration and clinical utility, and compared to the 8th TNM staging system using the Kaplan-Meier methods.
Journal ArticleDOI
Interleukin-1 receptor antagonist: a promising cytokine against human squamous cell carcinomas.
TL;DR: The interleukin-1 (IL-1) receptor antagonist (IL1RA) is a naturally occurring receptor antagonist that can compete with IL-1 in binding to the receptor as mentioned in this paper .
References
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Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal ArticleDOI
Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
Journal ArticleDOI
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Florian R. Greten,Lars Eckmann,Tim F. Greten,Jin Mo Park,Zhi-Wei Li,Laurence J. Egan,Laurence J. Egan,Martin F. Kagnoff,Michael Karin +8 more
TL;DR: It is shown that although deletion of IKKbeta in intestinal epithelial cells does not decrease inflammation, it leads to a dramatic decrease in tumor incidence without affecting tumor size, which is linked to increased epithelial apoptosis during tumor promotion.
Journal ArticleDOI
NF-κB functions as a tumour promoter in inflammation-associated cancer
Eli Pikarsky,Rinnat M. Porat,Ilan Stein,Rinat Abramovitch,Sharon Amit,Shafika Kasem,Elena Gutkovich-Pyest,Simcha Urieli-Shoval,Eithan Galun,Yinon Ben-Neriah +9 more
TL;DR: It is shown that the inflammatory process triggers hepatocyte NF-κB through upregulation of tumour-necrosis factor-α (TNFα) in adjacent endothelial and inflammatory cells, and is therefore a potential target for cancer prevention in chronic inflammatory diseases.
Journal ArticleDOI
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
TL;DR: A number of clinical trials of TNF-α antagonists alone, and in combination with other therapies, are currently underway in cancer patients, and there are suggestions of activity against advanced disease in advanced ovarian and renal cell cancer.