Journal ArticleDOI
Cancer-related inflammation.
TLDR
The role of cancer-associated inflammation and the particular role of MIF in malignant disease is discussed and there is evidence that the cytokine is produced by both malignant cells and infiltrating leukocytes.Citations
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Prognostic Role of the Pretreatment C-Reactive Protein/Albumin Ratio in Solid Cancers: A Meta-Analysis
TL;DR: It is suggested that CAR may be a potential prognostic marker in solid cancers, however, further large prospective studies should be conducted to explore the critical role of CAR in survival of cancer patients.
Journal ArticleDOI
Adipocytes as immune regulatory cells.
Silvana A. Vielma,Richard L. Klein,Richard L. Klein,Corinne A. Levingston,M. Rita I. Young,M. Rita I. Young +5 more
TL;DR: Modelling fibroblast-derived adipocytes and normal spleen cells as a model shows that adipocytes may be able to serve as immune regulatory cells to stimulate conventional immune cells to release a spectrum of immune mediators.
Journal ArticleDOI
Polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation in an in vitro model of carcinogenesis
TL;DR: All tested polyphenols were able to inhibit B[a]P-induced increases in markers of oxidative stress and inflammation, and to inhibit cellular transformation, with resveratrol being notable for the strongest preventive effect on cell transformation.
Journal ArticleDOI
Pathophysiological implications of neuroinflammation mediated HPA axis dysregulation in the prognosis of cancer and depression.
TL;DR: The role of neuroimmune axis and hyperactive HPA-axis in the case of both cancer and depression is focused on and therapeutics targeting the H PA-axis dysregulation could be effective in ameliorating symptoms of depression in cancer patients.
Journal ArticleDOI
Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer.
Tejaswini Subbannayya,Pamela Leal-Rojas,Pamela Leal-Rojas,Mustafa A. Barbhuiya,Remya Raja,Santosh Renuse,Gajanan Sathe,Sneha M. Pinto,Nazia Syed,Vishalakshi Nanjappa,Arun H. Patil,Patricia García,Nandini A. Sahasrabuddhe,Bipin G. Nair,Rafael Guerrero-Preston,Sanjay Navani,Pramod Kumar Tiwari,Vani Santosh,David Sidransky,T. S. Keshava Prasad,Harsha Gowda,Juan Carlos Roa,Akhilesh Pandey,Aditi Chatterjee,Aditi Chatterjee +24 more
TL;DR: The findings support the role of MIF in tumor aggressiveness and suggest its potential application as a therapeutic target for gallbladder cancer.
References
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Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal ArticleDOI
Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
Journal ArticleDOI
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Florian R. Greten,Lars Eckmann,Tim F. Greten,Jin Mo Park,Zhi-Wei Li,Laurence J. Egan,Laurence J. Egan,Martin F. Kagnoff,Michael Karin +8 more
TL;DR: It is shown that although deletion of IKKbeta in intestinal epithelial cells does not decrease inflammation, it leads to a dramatic decrease in tumor incidence without affecting tumor size, which is linked to increased epithelial apoptosis during tumor promotion.
Journal ArticleDOI
NF-κB functions as a tumour promoter in inflammation-associated cancer
Eli Pikarsky,Rinnat M. Porat,Ilan Stein,Rinat Abramovitch,Sharon Amit,Shafika Kasem,Elena Gutkovich-Pyest,Simcha Urieli-Shoval,Eithan Galun,Yinon Ben-Neriah +9 more
TL;DR: It is shown that the inflammatory process triggers hepatocyte NF-κB through upregulation of tumour-necrosis factor-α (TNFα) in adjacent endothelial and inflammatory cells, and is therefore a potential target for cancer prevention in chronic inflammatory diseases.
Journal ArticleDOI
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
TL;DR: A number of clinical trials of TNF-α antagonists alone, and in combination with other therapies, are currently underway in cancer patients, and there are suggestions of activity against advanced disease in advanced ovarian and renal cell cancer.