Journal ArticleDOI
Cancer-related inflammation.
TLDR
The role of cancer-associated inflammation and the particular role of MIF in malignant disease is discussed and there is evidence that the cytokine is produced by both malignant cells and infiltrating leukocytes.Citations
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The prognostic landscape of tumor-infiltrating immune cells in lung squamous cell carcinoma.
TL;DR: Wang et al. as discussed by the authors analyzed the immune-related transcriptional profiles of 490 lung squamous cell carcinoma (LUSC) patients from The Cancer Genome Atlas (TCGA) cohort, and evaluated and examined for their association with overall survival (OS) in LUSC.
Journal ArticleDOI
Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large B-cell lymphoma.
Yiwen Cao,Zhenhua Liu,Wen Wu,Ying Qian,Qin Shi,Rong Shen,Bin-Shen Ou-Yang,Pengpeng Xu,Shu Cheng,Jin Ye,Yiming Lu,Chao-Fu Wang,Chengde Yang,Li Wang,Wei-Li Zhao +14 more
TL;DR: The immunologic status was closely related to lymphoma progression, and this study provides new insights into the risk stratification of patients with DLBCL.
Journal ArticleDOI
Value of Cytokine Expression in Early Diagnosis and Prognosis of Tumor Metastasis
TL;DR: The findings suggest that plasma levels of IL-6, IL-8, and IL-12p70 and the percentage of lymphocytes could predict the recurrence, metastasis, and progression of cancer.
C-reactive protein, delirium, and other psychological symptoms among patients with advanced cancer
Koji Amano,Yutaka Hatano,Yoshinobu Matsuda,Isseki Maeda,Hiroto Ishiki,Tomofumi Miura,Kengo Imai,Tetsuo Hori,Yosuke Matsuda,Hiromi Funaki,Kozue Suzuki,Masanori Mori,Tatsuya Morita +12 more
TL;DR: It remains unclear whether a relationship exists between elevated C‐reactive protein (CRP) levels and delirium in advanced cancer.
References
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Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal ArticleDOI
Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
Journal ArticleDOI
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Florian R. Greten,Lars Eckmann,Tim F. Greten,Jin Mo Park,Zhi-Wei Li,Laurence J. Egan,Laurence J. Egan,Martin F. Kagnoff,Michael Karin +8 more
TL;DR: It is shown that although deletion of IKKbeta in intestinal epithelial cells does not decrease inflammation, it leads to a dramatic decrease in tumor incidence without affecting tumor size, which is linked to increased epithelial apoptosis during tumor promotion.
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NF-κB functions as a tumour promoter in inflammation-associated cancer
Eli Pikarsky,Rinnat M. Porat,Ilan Stein,Rinat Abramovitch,Sharon Amit,Shafika Kasem,Elena Gutkovich-Pyest,Simcha Urieli-Shoval,Eithan Galun,Yinon Ben-Neriah +9 more
TL;DR: It is shown that the inflammatory process triggers hepatocyte NF-κB through upregulation of tumour-necrosis factor-α (TNFα) in adjacent endothelial and inflammatory cells, and is therefore a potential target for cancer prevention in chronic inflammatory diseases.
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Smoldering and polarized inflammation in the initiation and promotion of malignant disease
TL;DR: A number of clinical trials of TNF-α antagonists alone, and in combination with other therapies, are currently underway in cancer patients, and there are suggestions of activity against advanced disease in advanced ovarian and renal cell cancer.