Journal ArticleDOI
Cancer-related inflammation.
TLDR
The role of cancer-associated inflammation and the particular role of MIF in malignant disease is discussed and there is evidence that the cytokine is produced by both malignant cells and infiltrating leukocytes.Citations
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Journal ArticleDOI
The inflammatory chemokine CCL5 and cancer progression.
TL;DR: This review summarizes updated information on the role of CCL5 and its receptor CCR5 in cancer cell proliferation, metastasis, and the formation of an immunosuppressive microenvironment and highlights the development of newer therapeutic strategies.
Journal ArticleDOI
The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review)
Shu-Wei Wang,Yueming Sun +1 more
TL;DR: The present review details the mechanisms and roles of the IL-6/JAK/STAT3 pathway in CRC, describes current therapeutic strategies, and the search for potential therapeutic approaches to treat CRC.
Journal ArticleDOI
Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
TL;DR: This review focuses on inflammaging and its contribution to various age-related diseases such as cardiovascular disease, cancer, neurodegenerative diseases, chronic obstructive pulmonary disease, diabetes, and rheumatoid arthritis.
Journal ArticleDOI
The prognostic landscape of tumor-infiltrating immune cell and immunomodulators in lung cancer.
TL;DR: The data suggest that tumor-infiltrating immune cells in lung cancer are likely to be important determinants of both prognosis and response to immunotherapies.
Journal ArticleDOI
Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment.
TL;DR: The results indicate that tumor-associated myeloid cells, including macrophages, DCs, and MDSCs all express immunosuppressive A2ARs that are potential targets of adenosine receptor blockers to enhance immune killing of tumors.
References
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Journal ArticleDOI
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen,Regina M. Krohn,Hongqi Lue,Julia L. Gregory,Alma Zernecke,Rory R. Koenen,Manfred Dewor,Ivan T. Georgiev,Andreas Schober,Lin Leng,Teake Kooistra,Gunter Fingerle-Rowson,Pietro Ghezzi,Robert Kleemann,Shaun R. McColl,Richard Bucala,Michael J. Hickey,Christian Weber +17 more
TL;DR: Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition and displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.
Journal ArticleDOI
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Sergei I. Grivennikov,Kepeng Wang,Daniel Mucida,C. Andrew Stewart,Bernd Schnabl,Dominik Jauch,Koji Taniguchi,Guann-Yi Yu,Christoph H. Österreicher,Kenneth E. Hung,Christian Datz,Ying Feng,Eric R. Fearon,Mohamed Oukka,Lino Tessarollo,Vincenzo Coppola,Felix Yarovinsky,Hilde Cheroutre,Lars Eckmann,Giorgio Trinchieri,Michael Karin +20 more
TL;DR: It is proposed that barrier deterioration induced by colorectal-cancer-initiating genetic lesions results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which in turn drives tumour growth.
Journal ArticleDOI
MIF signal transduction initiated by binding to CD74.
Lin Leng,Christine N. Metz,Yan Ju Fang,Jing-Jing Xu,Seamas C. Donnelly,John A. Baugh,Thomas Delohery,Yibang Chen,Robert A. Mitchell,Richard Bucala +9 more
TL;DR: It is reported herein that CD74, a Type II transmembrane protein, is a high-affinity binding protein for MIF, and it is identified as a natural ligand forCD74, which has been implicated previously in signaling and accessory functions for immune cell activation.
Journal ArticleDOI
Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis
Boryana K. Popivanova,Kazuya Kitamura,Yu Wu,Toshikazu Kondo,Takashi Kagaya,Shiuchi Kaneko,Masanobu Oshima,Chifumi Fujii,Naofumi Mukaida +8 more
TL;DR: TNF-alpha is identified as a crucial mediator of the initiation and progression of colitis-associated colon carcinogenesis and targeting TNF- alpha may be useful in treating colon cancer in individuals with UC.
Journal ArticleDOI
Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.
Robert J. Moore,David M. Owens,Gordon Stamp,Caroline H Arnott,Frances Burke,Nick East,Hazel Holdsworth,Lynn Turner,Barrett J. Rollins,Manolis Pasparakis,George Kollias,Frances R. Balkwill +11 more
TL;DR: Evidence is provided that a pro-inflammatory cytokine is required for de novo carcinogenesis and that TNF-α is important to the early stages of tumor promotion and strategies that neutralize TNF–/– production may be useful in cancer treatment and prevention.