Journal ArticleDOI
Cancer-related inflammation.
TLDR
The role of cancer-associated inflammation and the particular role of MIF in malignant disease is discussed and there is evidence that the cytokine is produced by both malignant cells and infiltrating leukocytes.Citations
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The inflammatory chemokine CCL5 and cancer progression.
TL;DR: This review summarizes updated information on the role of CCL5 and its receptor CCR5 in cancer cell proliferation, metastasis, and the formation of an immunosuppressive microenvironment and highlights the development of newer therapeutic strategies.
Journal ArticleDOI
The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review)
Shu-Wei Wang,Yueming Sun +1 more
TL;DR: The present review details the mechanisms and roles of the IL-6/JAK/STAT3 pathway in CRC, describes current therapeutic strategies, and the search for potential therapeutic approaches to treat CRC.
Journal ArticleDOI
Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
TL;DR: This review focuses on inflammaging and its contribution to various age-related diseases such as cardiovascular disease, cancer, neurodegenerative diseases, chronic obstructive pulmonary disease, diabetes, and rheumatoid arthritis.
Journal ArticleDOI
The prognostic landscape of tumor-infiltrating immune cell and immunomodulators in lung cancer.
TL;DR: The data suggest that tumor-infiltrating immune cells in lung cancer are likely to be important determinants of both prognosis and response to immunotherapies.
Journal ArticleDOI
Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment.
TL;DR: The results indicate that tumor-associated myeloid cells, including macrophages, DCs, and MDSCs all express immunosuppressive A2ARs that are potential targets of adenosine receptor blockers to enhance immune killing of tumors.
References
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Journal ArticleDOI
Interleukin-13 receptor α2 chain
TL;DR: The issue of whether interleukin‐13 receptor (IL‐13R), shown to be expressed on a variety of human cancers, is expressed in ovarian tumor samples was explored and whether this receptor serves as a biomarker and can be targeted by IL‐13 cytotoxin was examined.
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von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays.
Stefanie Galbán,Jinshui Fan,Jennifer L. Martindale,Chris Cheadle,Bryan E. Hoffman,Michael P. Woods,Gretchen Temeles,Jürgen Brieger,Jochen Decker,Myriam Gorospe +9 more
TL;DR: A novel function is uncovered for the pVHL tumor suppressor protein as regulator of protein translation through the TNF-α 3′-untranslated region.
Journal Article
Elevated IL-10 plasma levels correlate with poor prognosis in diffuse large B-cell lymphoma.
Ewa Lech-Marańda,Jacques Bienvenu,Anne-Sophie Michallet,Roch Houot,Tadeusz Robak,Bertrand Coiffier,Gilles Salles +6 more
TL;DR: It is confirmed in this large group of DLBCL patients that elevated plasma IL-10 levels correlated with adverse disease features and poor prognosis, and the plasma concentration of IL- 10 may be a useful marker for evaluation of disease activity.
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Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP beta-deficient mice.
Isabella Screpanti,Piero Musiani,Diana Bellavia,Manuela Cappelletti,Francesca B. Aiello,Marella Maroder,Luigi Frati,Andrea Modesti,Alberto Gulino,Valeria Poli +9 more
TL;DR: It is described here how the simultaneous inactivation of both IL-6 and C/EBP beta genes prevents the development of pathological traits of Castleman's disease observed in C/ EBP beta-deficient mice.
Journal ArticleDOI
Expression of Interleukin 11 and Its Receptor and Their Prognostic Value in Human Breast Cancer
TL;DR: IL-11 can be a predictor of poor prognosis in human breast cancer and was linked to poorer survival with Kaplan-Meier survival analysis.