Journal ArticleDOI
Cancer-related inflammation.
TLDR
The role of cancer-associated inflammation and the particular role of MIF in malignant disease is discussed and there is evidence that the cytokine is produced by both malignant cells and infiltrating leukocytes.Citations
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Journal ArticleDOI
The values of neutrophil-lymphocyte ratio and/or prostate-specific antigen in discriminating real Gleason score ≥ 7 prostate cancer from group of biopsy-based Gleason score ≤ 6.
Hanfeng Wang,Liangyou Gu,Yongjie Wu,Dan Feng,Junyao Duan,Xiaocong Wang,Yong Huang,Shengpan Wu,Jianwen Chen,Guangda Luo,Xu Zhang +10 more
TL;DR: Serum t PSA and NLR were significantly elevated among GS ≥ 7 PCa concurrently and the combination of tPSA andNLR might have additional benefit to biopsy on discriminating real GS ¬7 Pca from biopsy-based GS ≤ 6 PCa.
Journal ArticleDOI
Self-reported dietary flavonoid intake and serum markers of inflammation: the multiethnic cohort
Sabine Rohrmann,Yurii B. Shvetsov,Yukiko Morimoto,Lynne R. Wilkens,Kristine R. Monroe,Loic Le Marchand,Adrian A. Franke,Laurence N. Kolonel,Gertraud Maskarinec +8 more
TL;DR: The current results do not support a consistent association between dietary intake of flavonoids and markers of inflammatory processes.
Journal ArticleDOI
Dietary inflammatory index, risk and survival among women with endometrial cancer.
Christina M. Nagle,Torukiri I. Ibiebele,Nitin Shivappa,James R. Hébert,Amanda B. Spurdle,Penelope M. Webb,Penelope M. Webb +6 more
TL;DR: Higher E-DII scores, reflecting a more pro-inflammatory diet, were not associated with risk of EC, but secondary stratified analysis suggested greater inflammatory potential may be associated with EC risk in very obese women.
Journal ArticleDOI
Malignant epithelial tumors observed in hernia sacs
TL;DR: Gravity, inflammatory oncotaxis, and chemotactic agents are probably operative phenomena in the development of metastatic lesions in hernia sacs.
Journal ArticleDOI
Significant association between IL10-1082/-819 and TNF-308 haplotypes and the susceptibility to cervical carcinogenesis in women infected by Human papillomavirus.
Bárbara Simas Chagas,Rita de Cássia Pereira de Lima,Sérgio de Sá Leitão Paiva Júnior,R. C. O. Silva,M. N. Cordeiro,Jacinto da Costa Silva Neto,Marcus Vinicius de Aragão Batista,Anna Jéssica Duarte Silva,Ana Pavla Almeida Diniz Gurgel,Antonio Carlos de Freitas +9 more
TL;DR: The study indicates that the association of genetic polymorphism in inflammation‐related genes represents a risk to the susceptibility in the development of cervical cancer in women infected by HPVs 16, 18 and 58.
References
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Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal ArticleDOI
Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
Journal ArticleDOI
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Florian R. Greten,Lars Eckmann,Tim F. Greten,Jin Mo Park,Zhi-Wei Li,Laurence J. Egan,Laurence J. Egan,Martin F. Kagnoff,Michael Karin +8 more
TL;DR: It is shown that although deletion of IKKbeta in intestinal epithelial cells does not decrease inflammation, it leads to a dramatic decrease in tumor incidence without affecting tumor size, which is linked to increased epithelial apoptosis during tumor promotion.
Journal ArticleDOI
NF-κB functions as a tumour promoter in inflammation-associated cancer
Eli Pikarsky,Rinnat M. Porat,Ilan Stein,Rinat Abramovitch,Sharon Amit,Shafika Kasem,Elena Gutkovich-Pyest,Simcha Urieli-Shoval,Eithan Galun,Yinon Ben-Neriah +9 more
TL;DR: It is shown that the inflammatory process triggers hepatocyte NF-κB through upregulation of tumour-necrosis factor-α (TNFα) in adjacent endothelial and inflammatory cells, and is therefore a potential target for cancer prevention in chronic inflammatory diseases.
Journal ArticleDOI
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
TL;DR: A number of clinical trials of TNF-α antagonists alone, and in combination with other therapies, are currently underway in cancer patients, and there are suggestions of activity against advanced disease in advanced ovarian and renal cell cancer.