Journal ArticleDOI
Cancer-related inflammation.
TLDR
The role of cancer-associated inflammation and the particular role of MIF in malignant disease is discussed and there is evidence that the cytokine is produced by both malignant cells and infiltrating leukocytes.Citations
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Journal ArticleDOI
The inflammatory chemokine CCL5 and cancer progression.
TL;DR: This review summarizes updated information on the role of CCL5 and its receptor CCR5 in cancer cell proliferation, metastasis, and the formation of an immunosuppressive microenvironment and highlights the development of newer therapeutic strategies.
Journal ArticleDOI
The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review)
Shu-Wei Wang,Yueming Sun +1 more
TL;DR: The present review details the mechanisms and roles of the IL-6/JAK/STAT3 pathway in CRC, describes current therapeutic strategies, and the search for potential therapeutic approaches to treat CRC.
Journal ArticleDOI
Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
TL;DR: This review focuses on inflammaging and its contribution to various age-related diseases such as cardiovascular disease, cancer, neurodegenerative diseases, chronic obstructive pulmonary disease, diabetes, and rheumatoid arthritis.
Journal ArticleDOI
The prognostic landscape of tumor-infiltrating immune cell and immunomodulators in lung cancer.
TL;DR: The data suggest that tumor-infiltrating immune cells in lung cancer are likely to be important determinants of both prognosis and response to immunotherapies.
Journal ArticleDOI
Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment.
TL;DR: The results indicate that tumor-associated myeloid cells, including macrophages, DCs, and MDSCs all express immunosuppressive A2ARs that are potential targets of adenosine receptor blockers to enhance immune killing of tumors.
References
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Journal ArticleDOI
Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13.
Rachel F. Gabitass,Nicola E. Annels,Deborah D. Stocken,Hardev A. Pandha,Hardev A. Pandha,Gary Middleton,Gary Middleton +6 more
TL;DR: There was Th2 skewing for cytokine production in all three diseases, and importantly there were significant elevations of the pivotal Th2 cytokine interleukin-13, an increase that correlated with MDSC levels.
Journal ArticleDOI
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
Laura Soucek,Elizabeth R. Lawlor,Elizabeth R. Lawlor,Darya Soto,Ksenya Shchors,Lamorna Brown Swigart,Gerard I. Evan +6 more
TL;DR: It is shown in a β-cell tumor model that activation of Myc in vivo triggers rapid recruitment of mast cells to the tumor site—a recruitment that is absolutely required for macroscopic tumor expansion.
Journal ArticleDOI
Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population
Hasan Korkaya,Gwang Il Kim,April Davis,Fayaz Malik,N. Lynn Henry,Suthinee Ithimakin,Ahmed A. Quraishi,Nader Tawakkol,Rosemarie C. D'Angelo,Amanda K. Paulson,Susan Chung,Tahra Luther,Hayley J. Paholak,Suling Liu,Khaled A. Hassan,Qin Zen,Shawn G. Clouthier,Max S. Wicha +17 more
TL;DR: It is demonstrated that trastuzumab resistance may be mediated by an IL6 inflammatory loop and suggested that blocking this loop may provide alternative strategy to overcometrastuzuab resistance.
Journal ArticleDOI
Tumor-induced immune dysfunction : the macrophage connection
TL;DR: It is suggested that Mφs in different in vivo compartments may be differentially regulated by tumor‐derived molecules, which may deactivate tumor‐proximal (in situ) M φ populations while concurrently activating tumordistal M⩽s, imparting a twofold insult to the host's antitumor immune response.
Journal ArticleDOI
Macrophages Induce Invasiveness of Epithelial Cancer Cells Via NF-κB and JNK
Thorsten Hagemann,Julia L. Wilson,Hagen Kulbe,Ningfeng Fiona Li,David A. Leinster,Kellie A. Charles,Florian Klemm,Tobias Pukrop,Claudia Binder,Frances R. Balkwill +9 more
TL;DR: It is concluded that TNF-α, via NF-κB, and JNK induces MIF and EMMPRIN in macrophage to tumor cell cocultures and this leads to increased invasive capacity of the tumor cells.