Journal ArticleDOI
Cancer-related inflammation.
TLDR
The role of cancer-associated inflammation and the particular role of MIF in malignant disease is discussed and there is evidence that the cytokine is produced by both malignant cells and infiltrating leukocytes.Citations
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Journal ArticleDOI
Immunological Approaches Towards Cancer and Inflammation: A Cross Talk.
TL;DR: Monoclonal antibodies directed against TNF-α, VEGF, and IL-6 has shown promising results to ameliorate inflammation and cancer, while direct administration of IL-2 has been shown to cause tumor regression.
Journal ArticleDOI
Dual Role of GM-CSF as a Pro-Inflammatory and a Regulatory Cytokine: Implications for Immune Therapy.
Palash Bhattacharya,Isadore Budnick,Medha Singh,Muthusamy Thiruppathi,Khaled Alharshawi,Hatem A. Elshabrawy,Mark J. Holterman,Bellur S. Prabhakar +7 more
TL;DR: The pro-inflammatory and regulatory effects of GM-CSF appear to depend on the dose and the presence of other relevant cytokines in the context of an immune response, which will facilitate more appropriate use and thus enhance its clinical utility.
Journal ArticleDOI
Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis
Qiaofen Fu,Nan Chen,Chunlei Ge,Ruilei Li,Zhen Li,Baozhen Zeng,Chunyan Li,Ying Wang,Yuanbo Xue,Xin Song,Heng Li,Gaofeng Li +11 more
TL;DR: A meta-analysis confirmed the favorable prognostic role of the CD3+, CD4+, CD8+, FOXP3+, and CD20+ TILs in the overall survival of melanoma patients and found an association between the TILS present and improved overall survival.
Journal ArticleDOI
Environmental immune disruptors, inflammation and cancer risk.
Patricia A. Thompson,Mahin Khatami,Carolyn J. Baglole,Jun Sun,Shelley A. Harris,Eun-Yi Moon,Fahd Al-Mulla,Rabeah Al-Temaimi,Dustin G. Brown,Annamaria Colacci,Chiara Mondello,Jayadev Raju,Elizabeth P. Ryan,Jordan Woodrick,A. Ivana Scovassi,Neetu Singh,Monica Vaccari,Rabindra Roy,Stefano Forte,Lorenzo Memeo,Hosni Salem,Amedeo Amedei,Roslida Abd Hamid,Leroy Lowe,Tiziana Guarnieri,William H. Bisson +25 more
TL;DR: The role that the innate immune cells of inflammatory responses play in tumorigenesis is reviewed and the evidence linking environmental toxicant exposures with perturbation in the balance between pro- and anti-inflammatory responses is reviewed.
Journal ArticleDOI
Tumor Suppression and Promotion by Autophagy
Yenniffer Ávalos,Jimena Canales,Roberto Bravo-Sagua,Alfredo Criollo,Sergio Lavandero,Andrew F. G. Quest +5 more
TL;DR: Autophagy also functions as a cytoprotective mechanism under stress conditions, including hypoxia and nutrient starvation, that promotes tumor growth and resistance to chemotherapy in established tumors.
References
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Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal ArticleDOI
Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
Journal ArticleDOI
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Florian R. Greten,Lars Eckmann,Tim F. Greten,Jin Mo Park,Zhi-Wei Li,Laurence J. Egan,Laurence J. Egan,Martin F. Kagnoff,Michael Karin +8 more
TL;DR: It is shown that although deletion of IKKbeta in intestinal epithelial cells does not decrease inflammation, it leads to a dramatic decrease in tumor incidence without affecting tumor size, which is linked to increased epithelial apoptosis during tumor promotion.
Journal ArticleDOI
NF-κB functions as a tumour promoter in inflammation-associated cancer
Eli Pikarsky,Rinnat M. Porat,Ilan Stein,Rinat Abramovitch,Sharon Amit,Shafika Kasem,Elena Gutkovich-Pyest,Simcha Urieli-Shoval,Eithan Galun,Yinon Ben-Neriah +9 more
TL;DR: It is shown that the inflammatory process triggers hepatocyte NF-κB through upregulation of tumour-necrosis factor-α (TNFα) in adjacent endothelial and inflammatory cells, and is therefore a potential target for cancer prevention in chronic inflammatory diseases.
Journal ArticleDOI
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
TL;DR: A number of clinical trials of TNF-α antagonists alone, and in combination with other therapies, are currently underway in cancer patients, and there are suggestions of activity against advanced disease in advanced ovarian and renal cell cancer.