Journal ArticleDOI
Cancer-related inflammation.
TLDR
The role of cancer-associated inflammation and the particular role of MIF in malignant disease is discussed and there is evidence that the cytokine is produced by both malignant cells and infiltrating leukocytes.Citations
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Properties of donated red blood cell components from patients with hereditary hemochromatosis.
Caroline Sut,Hind Hamzeh-Cognasse,Sandrine Laradi,Vincent Bost,Christine Aubrège,Sophie Acquart,Martine Vignal,Nadia Boutahar,Charles Antoine Arthaud,Marie Ange Eyraud,Bruno Pozzetto,Pierre Tiberghien,Olivier Garraud,Fabrice Cognasse +13 more
TL;DR: The quality of RBCs obtained from HH patients with those of non‐HH Rbcs, within the allowed 42‐day storage period are compared.
Journal ArticleDOI
Associations between Nutritional and Immune Status and Clinicopathologic Factors in Patients with Pancreatic Cancer: A Comprehensive Analysis.
TL;DR: In this paper, the authors assess and analyze the nutritional status (NS) and immune status of patients undergoing curative pancreatic resection in the Department of Digestive Tract Surgery of the Medical University (Katowice, Poland).
Journal ArticleDOI
The cellular immunotherapy of integrated photothermal anti-oxidation Pd-Se nanoparticles in inhibition of the macrophage inflammatory response in rheumatoid arthritis.
TL;DR: The experiments show that the combined therapy of eliminating ⋅OH with Se NPs and utilizing PTT with Pd NPs could effectively reduce the inflammatory response in macrophages more effectively than either individual NP treatment.
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Stromal-epithelial crosstalk provides a suitable microenvironment for the progression of ovarian cancer cells in vitro.
TL;DR: It is found that the stromal–epithelial crosstalk provided a suitable microenvironment for the progression of ovarian cancer cells in vitro.
Journal ArticleDOI
Autophagy-A Hidden but Important Actor on Oral Cancer Scene.
Totan Alexandra,Imre Melescanu Marina,Miricescu Daniela,Stanescu Iulia Ioana,BencZe Maria,Radulescu Radu,Tancu Ana Maria,Spinu Tudor,Greabu Maria +8 more
TL;DR: Understanding how to overcome cytoprotective autophagy and how to take advantage of autophagic cell death is critical in order to enhance the cancer cells sensitivity to particular therapeutic agents.
References
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Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal ArticleDOI
Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
Journal ArticleDOI
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Florian R. Greten,Lars Eckmann,Tim F. Greten,Jin Mo Park,Zhi-Wei Li,Laurence J. Egan,Laurence J. Egan,Martin F. Kagnoff,Michael Karin +8 more
TL;DR: It is shown that although deletion of IKKbeta in intestinal epithelial cells does not decrease inflammation, it leads to a dramatic decrease in tumor incidence without affecting tumor size, which is linked to increased epithelial apoptosis during tumor promotion.
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NF-κB functions as a tumour promoter in inflammation-associated cancer
Eli Pikarsky,Rinnat M. Porat,Ilan Stein,Rinat Abramovitch,Sharon Amit,Shafika Kasem,Elena Gutkovich-Pyest,Simcha Urieli-Shoval,Eithan Galun,Yinon Ben-Neriah +9 more
TL;DR: It is shown that the inflammatory process triggers hepatocyte NF-κB through upregulation of tumour-necrosis factor-α (TNFα) in adjacent endothelial and inflammatory cells, and is therefore a potential target for cancer prevention in chronic inflammatory diseases.
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Smoldering and polarized inflammation in the initiation and promotion of malignant disease
TL;DR: A number of clinical trials of TNF-α antagonists alone, and in combination with other therapies, are currently underway in cancer patients, and there are suggestions of activity against advanced disease in advanced ovarian and renal cell cancer.