Journal ArticleDOI
Cancer-related inflammation.
TLDR
The role of cancer-associated inflammation and the particular role of MIF in malignant disease is discussed and there is evidence that the cytokine is produced by both malignant cells and infiltrating leukocytes.Citations
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Journal ArticleDOI
The inflammatory chemokine CCL5 and cancer progression.
TL;DR: This review summarizes updated information on the role of CCL5 and its receptor CCR5 in cancer cell proliferation, metastasis, and the formation of an immunosuppressive microenvironment and highlights the development of newer therapeutic strategies.
Journal ArticleDOI
The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review)
Shu-Wei Wang,Yueming Sun +1 more
TL;DR: The present review details the mechanisms and roles of the IL-6/JAK/STAT3 pathway in CRC, describes current therapeutic strategies, and the search for potential therapeutic approaches to treat CRC.
Journal ArticleDOI
Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
TL;DR: This review focuses on inflammaging and its contribution to various age-related diseases such as cardiovascular disease, cancer, neurodegenerative diseases, chronic obstructive pulmonary disease, diabetes, and rheumatoid arthritis.
Journal ArticleDOI
The prognostic landscape of tumor-infiltrating immune cell and immunomodulators in lung cancer.
TL;DR: The data suggest that tumor-infiltrating immune cells in lung cancer are likely to be important determinants of both prognosis and response to immunotherapies.
Journal ArticleDOI
Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment.
TL;DR: The results indicate that tumor-associated myeloid cells, including macrophages, DCs, and MDSCs all express immunosuppressive A2ARs that are potential targets of adenosine receptor blockers to enhance immune killing of tumors.
References
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Journal ArticleDOI
An essential regulatory role for macrophage migration inhibitory factor in T-cell activation
Michael Bacher,Christine N. Metz,Thierry Calandra,Katrin Mayer,Jason Chesney,Michael Lohoff,Diethard Gemsa,Thomas M. Donnelly,Richard Bucala +8 more
TL;DR: It is reported that MIF plays an important regulatory role in the activation of T cells induced by mitogenic or antigenic stimuli and assigned a previously unsuspected but critical role for MIF in antigen-specific immune responses.
Journal ArticleDOI
A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity
James D. Hudson,Mahmood A. Shoaibi,Roberta Maestro,Amancio Carnero,Gregory J. Hannon,David Beach +5 more
TL;DR: The observation that a proinflammatory cytokine, MIF, is capable of functionally inactivating a tumor suppressor, p53, may provide a link between inflammation and tumorigenesis.
Journal ArticleDOI
Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis
Sean L. Petersen,Lai Wang,Asligul Yalcin-Chin,Lin Li,Michael Peyton,John D. Minna,Patrick G. Harran,Xiaodong Wang +7 more
TL;DR: A small molecule mimetic of Smac/Diablo that specifically counters the apoptosis-inhibiting activity of IAP proteins has been shown to enhance apoptosis induced by cell surface death receptors as well as chemotherapeutic drugs.
Journal ArticleDOI
CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex.
Xuerong Shi,Lin Leng,Tian Wang,Wenkui Wang,Xin Du,Ji Li,Courtney McDonald,Zun Chen,James W. Murphy,Elias Lolis,Paul W. Noble,Warren Knudson,Richard Bucala +12 more
TL;DR: In this paper, the authors used the CD74-and CD44-deficient COS-7/M6 cell to create stable transfectants expressing CD74, CD44, and a truncated CD44 lacking its intracytoplasmic signaling domain.
Journal Article
Multiple Actions of the Chemokine CXCL12 on Epithelial Tumor Cells in Human Ovarian Cancer
Chris J. Scotton,Julia L. Wilson,Kate M. Scott,Gordon Stamp,George D. Wilbanks,Simon P. Fricker,Gary Bridger,Frances R. Balkwill +7 more
TL;DR: The chemokine CXCL12 may have multiple biological effects in ovarian cancer, stimulating cell migration and invasion through extracellular matrix, as well as DNA synthesis and establishment of a cytokine network in situations that are suboptimal for tumor cell growth.