Journal ArticleDOI
Cancer-related inflammation.
TLDR
The role of cancer-associated inflammation and the particular role of MIF in malignant disease is discussed and there is evidence that the cytokine is produced by both malignant cells and infiltrating leukocytes.Citations
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Journal ArticleDOI
The inflammatory chemokine CCL5 and cancer progression.
TL;DR: This review summarizes updated information on the role of CCL5 and its receptor CCR5 in cancer cell proliferation, metastasis, and the formation of an immunosuppressive microenvironment and highlights the development of newer therapeutic strategies.
Journal ArticleDOI
The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review)
Shu-Wei Wang,Yueming Sun +1 more
TL;DR: The present review details the mechanisms and roles of the IL-6/JAK/STAT3 pathway in CRC, describes current therapeutic strategies, and the search for potential therapeutic approaches to treat CRC.
Journal ArticleDOI
Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
TL;DR: This review focuses on inflammaging and its contribution to various age-related diseases such as cardiovascular disease, cancer, neurodegenerative diseases, chronic obstructive pulmonary disease, diabetes, and rheumatoid arthritis.
Journal ArticleDOI
The prognostic landscape of tumor-infiltrating immune cell and immunomodulators in lung cancer.
TL;DR: The data suggest that tumor-infiltrating immune cells in lung cancer are likely to be important determinants of both prognosis and response to immunotherapies.
Journal ArticleDOI
Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment.
TL;DR: The results indicate that tumor-associated myeloid cells, including macrophages, DCs, and MDSCs all express immunosuppressive A2ARs that are potential targets of adenosine receptor blockers to enhance immune killing of tumors.
References
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Journal ArticleDOI
CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages
David G. DeNardo,Jairo Barreto,Pauline Andreu,Lesley Vasquez,Lesley Vasquez,David Tawfik,Nikita S. Kolhatkar,Lisa M. Coussens +7 more
TL;DR: Together, these data indicate that antitumor acquired immune programs can be usurped in protumor microenvironments and instead promote malignancy by engaging cellular components of the innate immune system functionally involved in regulating epithelial cell behavior.
Journal ArticleDOI
Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.
TL;DR: It is demonstrated that, following incubation of sensitive lymphoid cells with specific antigen for 24 hr, a nondialyzable substance is detected in the cell-free supernatants which inhibits the migration of normal peritoneal cells.
Journal ArticleDOI
Gastric cancer originating from bone marrow-derived cells.
JeanMarie Houghton,Calin Stoicov,Sachiyo Nomura,Sachiyo Nomura,Arlin B. Rogers,Jane E. Carlson,Hanchen Li,Xun Cai,James G. Fox,James R. Goldenring,James R. Goldenring,Timothy C. Wang +11 more
TL;DR: It is shown that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter induces repopulation of the stomach with BMDCs, suggesting that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.
Journal ArticleDOI
IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis
TL;DR: IKKbeta orchestrates inflammatory crosstalk between hepatocytes and hematopoietic-derived cells that promotes chemical hepatocarcinogenesis and blocks excessive DEN-induced carcinogenesis in Ikkbeta(Deltahep) mice.
Journal ArticleDOI
MIF as a glucocorticoid-induced modulator of cytokine production
Thierry Calandra,Jürgen Bernhagen,Christine N. Metz,Lori Spiegel,Michael Bacher,Thomas M. Donnelly,Anthony Cerami,Richard Bucala +7 more
TL;DR: The unexpected finding that low con-centrations of glucocorticoids induce rather than inhibit MIF production from macrophages is reported, identifying a unique counter-regulatory system that functions to control inflammatory and immune responses.