Journal ArticleDOI
Cancer-related inflammation.
TLDR
The role of cancer-associated inflammation and the particular role of MIF in malignant disease is discussed and there is evidence that the cytokine is produced by both malignant cells and infiltrating leukocytes.Citations
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Journal ArticleDOI
Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages
Jacinta P. W. Lee,Andrew Murray Foote,Huapeng Fan,Celia Peral de Castro,Tali Lang,Sarah Jones,Nichita Gavrilescu,Kingston H. G. Mills,Michelle Theresa Leech,Eric F Morand,James Harris +10 more
TL;DR: It is demonstrated that autophagic regulation of mitochondrial ROS plays a pivotal role in the regulation of inflammatory cytokine secretion in macrophages, with potential implications for the pathogenesis of inflammatory diseases and cancers.
Journal ArticleDOI
Dendritic cell defects in the colorectal cancer
TL;DR: New information is summarized on the role of the DCs in colon cancer development and/or progression representing a tumor-escape mechanism employed by cancer cells to elude host immunosurveillance.
Journal ArticleDOI
The Role of IL-33-Dependent Inflammation in the Tumor Microenvironment.
TL;DR: This review will present the current knowledge on the role of IL-33 in the microenvironment of different tumors, and explain how IL- 33 modulates the tumor-associated inflammatory microenvironment to restrain or promote tumorigenesis.
Journal ArticleDOI
The Predictive Value of Inflammation-Related Peripheral Blood Measurements in Cancer Staging and Prognosis.
Joanna L. Sylman,Joanna L. Sylman,Joanna L. Sylman,Annachiara Mitrugno,Michelle Atallah,Garth W. Tormoen,Joseph J. Shatzel,Samuel Tassi Yunga,Todd H. Wagner,Todd H. Wagner,John T. Leppert,John T. Leppert,Parag Mallick,Owen J. T. McCarty +13 more
TL;DR: The benefits of combining multiple types of measurements and longitudinal tracking to improve staging and prognosis prediction of patients with cancer, and the ability of novel in silico frameworks to leverage this high-dimensional data.
Journal ArticleDOI
IL-35 induces N2 phenotype of neutrophils to promote tumor growth.
Jiu-Ming Zou,Jian Qin,Yong-Chao Li,Yu Wang,Dong Li,Yu Shu,Chao Luo,Shan-Shan Wang,Gang Chi,Fang Guo,Gui-Mei Zhang,Zuo-Hua Feng +11 more
TL;DR: It is reported that IL-35 can induce N2 neutrophil polarization (protumor phenotype) by increasing G-CSF and IL-6 production, and promote neutrophils infiltration into tumor microenvironment.
References
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Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal ArticleDOI
Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
Journal ArticleDOI
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.
Florian R. Greten,Lars Eckmann,Tim F. Greten,Jin Mo Park,Zhi-Wei Li,Laurence J. Egan,Laurence J. Egan,Martin F. Kagnoff,Michael Karin +8 more
TL;DR: It is shown that although deletion of IKKbeta in intestinal epithelial cells does not decrease inflammation, it leads to a dramatic decrease in tumor incidence without affecting tumor size, which is linked to increased epithelial apoptosis during tumor promotion.
Journal ArticleDOI
NF-κB functions as a tumour promoter in inflammation-associated cancer
Eli Pikarsky,Rinnat M. Porat,Ilan Stein,Rinat Abramovitch,Sharon Amit,Shafika Kasem,Elena Gutkovich-Pyest,Simcha Urieli-Shoval,Eithan Galun,Yinon Ben-Neriah +9 more
TL;DR: It is shown that the inflammatory process triggers hepatocyte NF-κB through upregulation of tumour-necrosis factor-α (TNFα) in adjacent endothelial and inflammatory cells, and is therefore a potential target for cancer prevention in chronic inflammatory diseases.
Journal ArticleDOI
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
TL;DR: A number of clinical trials of TNF-α antagonists alone, and in combination with other therapies, are currently underway in cancer patients, and there are suggestions of activity against advanced disease in advanced ovarian and renal cell cancer.