Cannabis sativa: The Plant of the Thousand and One Molecules
TLDR
Prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.Abstract:
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cultures. Additionally, an entire section is devoted to hemp trichomes, in the light of their importance as phytochemical factories. Ultimately, prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.read more
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Sphingomonas cannabina sp. nov., isolated from Cannabis sativa L. 'Cheungsam'.
Doeun Jeon,Ling Min Jiang,Yuxin Peng,Jiyoon Seo,Zhun Li,Seung Hwan Park,Rae-Dong Jeong,Soon Ju Park,Jae Cheol Jeong,Jiyoung Lee +9 more
TL;DR: The results of phylogenetic anlayses, polyphasic studies, and Phylogenetic analyses revealed that strain DM2-R-LB4T represents a novel species of the genus Sphingomonas, for which the name Spindingomonas cannabina sp.
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Vaporized Cannabis differentially modulates sexual behavior of female rats according to the dose.
Alejandra Mondino,Santiago Fernández,Carlos García-Carnelli,María José Castro,Eleuterio Umpiérrez,Pablo Torterolo,Atilio Falconi,Daniella Agrati +7 more
TL;DR: A differential effect of vaporized Cannabis according to the dose employed, suggests that it modulates sexual behavior in a complex way, impacting neural circuits that control different aspects of this social behavior.
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Anti-cancer potential of cannabis terpenes in a taxol-resistant model of breast cancer
TL;DR: In this article, the effects of terpenes found in cannabis in in vitro chemotherapy-resistant model of breast cancer were evaluated, and it was shown that combining with the flavonoid kaempferol potentiated the cytotoxic effects of ocimene, terpinolene, and {beta}-myrcene.
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Future trends in I&M: The next generation of measurement technology for medicinal cannabis production
TL;DR: For example, medicinal cannabis is currently legal in over 40 countries and 33 states in the US, with the global sector estimated by some industry analysts to be worth over USD 626 billion by 2024 as discussed by the authors.
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