Cannabis sativa: The Plant of the Thousand and One Molecules
TLDR
Prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.Abstract:
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cultures. Additionally, an entire section is devoted to hemp trichomes, in the light of their importance as phytochemical factories. Ultimately, prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.read more
Citations
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Neurocognitive consequences of chronic cannabis use: a systematic review and meta-analysis.
TL;DR: There was a low cross-sectional association between neurocognitive impairments and chronic cannabis use in cognitive impulsivity, cognitive flexibility, attention, short-term memory and long- term memory.
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Uncovering the Hidden Antibiotic Potential of Cannabis.
Maya A. Farha,Omar M. El-Halfawy,Omar M. El-Halfawy,Robert T. Gale,Craig R. MacNair,Lindsey A. Carfrae,Xiong Zhang,Nicholas G. Jentsch,Jakob Magolan,Eric D. Brown +9 more
TL;DR: It is demonstrated that cannabinoids work in combination with polymyxin B against multi-drug resistant Gram-negative pathogens, revealing the broad-spectrum therapeutic potential for cannabinoids.
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Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study.
Adeyinka Charles Adejumo,Samson Alliu,Tokunbo Ajayi,Kelechi Lauretta Adejumo,Oluwole Adegbala,Nnaemeka Onyeakusi,Akintunde M Akinjero,Modupeoluwa Durojaiye,Terence N. Bukong,Terence N. Bukong +9 more
TL;DR: A population-based case-control study of 5,950,391 patients using the 2014 Healthcare Cost and Utilization Project, Nationwide Inpatient Survey (NIS) discharge records of patients 18 years and older suggests that cannabis use is associated with lower prevalence of NAFLD in patients.
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Medical Cannabis for Older Patients
TL;DR: A pragmatic clinical approach to a rational dialogue with older patients is proposed, highlighting the importance of individual benefit–risk assessment and shared patient–clinician decision making.
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Analysis of Phenolic Compounds in Commercial Cannabis sativa L. Inflorescences Using UHPLC-Q-Orbitrap HRMS
Luana Izzo,Luigi Castaldo,Alfonso Narváez,Giulia Graziani,Anna Gaspari,Yelko Rodríguez-Carrasco,Alberto Ritieni +6 more
TL;DR: Results highlighted a high content of cannflavin A and B in inflorescence analyzed samples, which appear to be cannabis-specific, and could be considered as a potential novel source of polyphenols intended for nutraceutical formulations.
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