Cannabis sativa: The Plant of the Thousand and One Molecules
TLDR
Prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.Abstract:
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cultures. Additionally, an entire section is devoted to hemp trichomes, in the light of their importance as phytochemical factories. Ultimately, prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.read more
Citations
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Journal ArticleDOI
Glandular trichome development, morphology, and maturation are influenced by plant age and genotype in high THC-containing cannabis (Cannabis sativa L.) inflorescences
TL;DR: The influence of plant age and genotype on trichome development, morphology, and maturation has not been extensively studied as mentioned in this paper , and the influence of genotype and plant age on distribution, numbers, and morphological features should lead to a better understanding of cannabis quality and consistency.
Journal ArticleDOI
Identification of p-Coumaric Acid and Ethyl p-Coumarate as the Main Phenolic Components of Hemp (Cannabis sativa L.) Roots
Chang Min Oh,Joon-Yong Choi,In Ah Bae,Hong Taek Kim,Seong Su Hong,Jay Kyun Noah,Yong Chool Boo +6 more
TL;DR: In this paper , the major phenolic components contained in hemp root were identified by using high-performance liquid chromatography with photodiode array detection (HPLC-DAD) analysis.
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Los rankings académicos y la distribución por género de las universidades
TL;DR: In this article, the authors examined the distribution of the universities by gender through a percentage of women within the student body, and checked if such distribution has any relation to the position of universities in the university rankings.
Book ChapterDOI
Transgenerational inheritance and its modulation by environmental cues.
TL;DR: In this article , the authors discuss the evidence of transgenerational inheritance to a range of different environmental cues, both epidemiological in humans and experimental in rodent models, and draw a detailed picture of how our environment can influence our epigenomes, ultimately reshaping our phenotypes.
Journal ArticleDOI
Evaluation of two different Cannabis sativa L. extracts as antioxidant and neuroprotective agents
TL;DR: It is demonstrated that polyphenolic extract was not cytotoxic and exhibited cytoprotective properties against hydrogen peroxide and antioxidant response decreasing reactive oxygen species (ROS) production, and these extracts could be a source of compounds with potential benefit on human health, especially related to neurodegenerative disorders.
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