Cannabis sativa: The Plant of the Thousand and One Molecules
TLDR
Prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.Abstract:
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cultures. Additionally, an entire section is devoted to hemp trichomes, in the light of their importance as phytochemical factories. Ultimately, prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.read more
Citations
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The effect of various thermochemical pretreatment methods on the biomethanisation of hemp (Cannabis sativa) hurd and kinetic analysis
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Clinical Research Evidence Supporting Administration and Dosing Recommendations of Medicinal Cannabis as Analgesic in Cancer Patients
TL;DR: In this paper , a review aims to elucidate clinical research supporting administration of medicinal cannabis in cancer patients for analgesic purposes, focusing on the effect of the cannabinoids on the endocannabinoid system (ECS).
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Non-Invasive and Confirmatory Differentiation of Hermaphrodite from Both Male and Female Cannabis Plants Using a Hand-Held Raman Spectrometer
Nicolas K Goff,James F. Guenther,J. K. M. Roberts,Mickal Adler,Michael Dalle Molle,Greg Mathews,Dmitry Kurouski +6 more
TL;DR: The results show that the biochemistry of male, female and hermaphroditic cannabis plants is drastically different which allows for their confirmatory identification using a hand-held Raman spectrometer, and the developed optical sensing approach can transform cannabis farming in the U.S. and overseas.
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Total yeast and mold levels in high THC-containing cannabis (Cannabis sativa L.) inflorescences are influenced by genotype, environment, and pre-and post-harvest handling practices
TL;DR: In this paper , the authors used potato dextrose agar (PDA) with 140 mg/L streptomycin sulfate to measure the Colony-Forming Units (cfu) of the cannabis inflorescence.
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Influence of Cultivar, Harvest Date, and Selected Weather Conditions on the Essential Oils Content in Inflorescences of Hemp Cannabis sativa L
TL;DR: In this paper , the impact of two harvesting dates, temperature, and precipitation on the content of essential oils in inflorescences of three hemp cultivars in fresh and dry plant matter was assessed.
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