Cannabis sativa: The Plant of the Thousand and One Molecules
TLDR
Prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.Abstract:
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cultures. Additionally, an entire section is devoted to hemp trichomes, in the light of their importance as phytochemical factories. Ultimately, prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.read more
Citations
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Classification of Various Marijuana Varieties by Raman Microscopy and Chemometrics
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TL;DR: In this article, the potential of secondary metabolites of C. sativa L. in the treatment of oral and oral diseases was investigated. But, the authors focused on the use of Cannabidiol (CBD), one of several secondary metabolites produced by C. sitiva L, in traditional Asian medicine for toothpain management, prevention of dental caries and reduction in gum inflammation.
Book ChapterDOI
The United Chemicals of Cannabis: Beneficial Effects of Cannabis Phytochemicals on the Brain and Cognition
TL;DR: The scientific evidence surrounding the benefits of CBD and other specific key phytochemicals in cannabis, including linalool, α-pinene, β-caryophyllene, flavonoids and anthocyanin, on brain health and cognition is explored.
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Naturally Occurring Cannabinoids and their Role in Modulation of Cardiovascular Health
TL;DR: In this paper, the role of the endocannabinoid system (ECS) in various cardiovascular conditions has been a subject of great interest, which is composed of cannabinoid receptors, their endogeno...
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