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Open AccessJournal ArticleDOI

Cannabis sativa: The Plant of the Thousand and One Molecules

TLDR
Prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.
Abstract
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cultures. Additionally, an entire section is devoted to hemp trichomes, in the light of their importance as phytochemical factories. Ultimately, prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.

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Journal ArticleDOI

The influence of cannabis smoke and cannabis vapour on simulated lung surfactant function under physiologically relevant conditions

TL;DR: The trends noted were ascribed to two factors operating synergistically, namely the amount of Δ9‐THC (plus others) within the aerosolised samples and the associated toxicity profile, and further research is required to establish mass‐balance effects (ie, titrated outputs).
Journal ArticleDOI

A Proteomic View of Cellular and Molecular Effects of Cannabis

TL;DR: In this paper, a comprehensive overview of both in vitro and in vivo proteomic studies involving the cellular and molecular effects of cannabis and cannabis-derived compounds is provided, which is an efficient tool to rigorously elucidate the mechanistic effects of Cannabis on the human body in a cell and tissue-specific manner, drawing conclusions associated with its toxicity as well as therapeutic benefits, safety and efficacy profiles.
Book ChapterDOI

Clinical Pharmacokinetics of Cannabinoids and Potential Drug-Drug Interactions.

TL;DR: In this paper, the authors summarized the current knowledge on the pharmacokinetics and metabolic fate of cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) in humans and discussed relevant drug-drug interactions.
Journal ArticleDOI

A narrative review of the ethnomedicinal usage of Cannabis sativa Linnaeus as traditional phytomedicine by folk medicine practitioners of Bangladesh.

TL;DR: In this article, a review of the traditional usage of Cannabis sativa as a phytomedicine from published ethnomedicinal studies is presented, which is an effort to retrieve the traditional use of cannabis sativa from published literature.
Journal ArticleDOI

An advanced method for the release, enrichment and purification of high-quality Arabidopsis thaliana rosette leaf trichomes enables profound insights into the trichome proteome

TL;DR: In this article , the authors proposed an advanced method for the isolation of A. thaliana leaf trichomes that outcompetes previous procedures regarding yield and purity, which can be applied to retrieve diverse glandular and non-glandular trichome types from other plant species.
References
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Journal ArticleDOI

In vitro: Response of plant growth regulators and antimalformins on conidia germination of Fusarium mangiferae and incidence of mango malformation

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Journal ArticleDOI

Adverse Health Effects of Marijuana Use

TL;DR: As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration, but enough information is available to cause concern.
Journal ArticleDOI

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

TL;DR: A comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy is provided.
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