Cannabis sativa: The Plant of the Thousand and One Molecules
TLDR
Prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.Abstract:
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cultures. Additionally, an entire section is devoted to hemp trichomes, in the light of their importance as phytochemical factories. Ultimately, prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.read more
Citations
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Evaluation of the carotenoid and fat-soluble vitamin profile of industrial hemp inflorescence by liquid chromatography coupled to mass spectrometry and photodiode-array detection
TL;DR: In this paper , 22 target carotenoids and fat-soluble vitamins were analyzed in the inflorescences of seven Italian industrial hemp varieties cultivated outdoor, and the analytes were extracted by cold saponification to avoid artifacts and analyzed by high-performance liquid chromatography coupled with Selected reaction monitoring mass spectrometry.
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Terpene profiles of different Cannabis plant varieties, cultivated in NYSK Holdings, Skopje
Tatjana Rusevska,Aleksandar Micev,Ema Malezi,Mirela R. Mladenovska,Rade Rusevski,Marija Darkovska Serafimovska,Tijana Serafimovska,Aleksandar Rusevski,Sasho Stefanoski,Zlatko Keskovski +9 more
TL;DR: In this article , the authors present the results of a study at the Macedonian Academy of Sciences and Arts and the results are presented in the form of a set of diagrams. 1.
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Isolation of Biologically Active Compounds from Cannabis sativa L. Inflorescences by Using Different Extraction Solvents and Evaluation of Antimicrobial Activity
Sana Ullah,Algimanta Kundrotaitė,Renata Žvirdauskienė,Ausra Baksinskaite,Karolina Barcauskaite +4 more
TL;DR: In this article , a comparative analysis of three different solvents: deionized water, 70% methanol (MeOH), and 2% Triton X-100, for phytochemicals in hemp inflorescences was carried out.
Journal ArticleDOI
Influence of Germination Conditions and Parameters on the Content of Total Phenolic Compounds and Scavenging Activity in Germinated Seeds
Journal ArticleDOI
Genome-Scale Metabolic Reconstruction, Non-Targeted LC-QTOF-MS Based Metabolomics Data, and Evaluation of Anticancer Activity of Cannabis sativa Leaf Extracts
M. M. Santamaría-Torres,Mónica P. Cala,Marcela Guevara-Suarez,Silvia Restrepo,Andrea del Pilar Sánchez-Camargo,Miguel Fernández-Niño,Maria Corujo,Javier Cifuentes,Julian A Serna,Juan C. Cruz,Carolina Muñoz-Camargo,Andrés Fernando González Barrios +11 more
TL;DR: In this paper , a genome-scale metabolic reconstruction of C. sativa is described and contextualized using LC-QTOF-MS metabolic data obtained from the leaf extract from plants grown in the region of Pesca-Boyaca, Colombia under greenhouse conditions at the Clever Leaves facility.
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