Cannabis sativa: The Plant of the Thousand and One Molecules
TLDR
Prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.Abstract:
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cultures. Additionally, an entire section is devoted to hemp trichomes, in the light of their importance as phytochemical factories. Ultimately, prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.read more
Citations
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Journal ArticleDOI
Effect of dietary hempseed cake on milk performance and haemato-chemicals in lactating Alpine dairy goats.
Ž. Klir Šalavardić,Josip Novoselec,Mislav Đidara,Zvonimir Steiner,Suzana Ćavar,A. Modić Šabić,Zvonko Antunović +6 more
TL;DR: In this paper, the effects of hempseed cake on milk production and quality, as well as haemato-chemical parameters in Alpine goats were evaluated over 45 days, where all goats were fed meadow hay supplemented with 1.2 kg/day feed mixture.
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The Effects of Cannabis sativa L. Extract on Oxidative Stress Markers In Vivo
Asta Kubiliene,Karolina Mickute,Juste Baranauskaite,Mindaugas Marksa,Arunas Liekis,Ilona Sadauskiene +5 more
TL;DR: In this article, the authors evaluated the possible antioxidative effect of Cannabis sativa L. extract (CE) on malondialdehyde (MDA) and glutathione (GSH) concentrations as well as on catalase (CAT) activity in BALB/c mice.
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Plant Fibers and Phenolics: A Review on Their Synthesis, Analysis and Combined Use for Biomaterials with New Properties
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Flavonoid and cannabinoid impact on the ocular surface.
TL;DR: Flavonoids and cannabinoids show promise as potential complementary treatment for allergic diseases because of their anti-inflammatory and antiallergic properties and show potential in becoming adjuvant treatment strategies for improving quality of life while also managing ocular surface disease processes.
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Targeting natural products against SARS-CoV-2
Ahmed Al-Harrasi,Tapan Behl,Tanuj Upadhyay,Sridevi Chigurupati,Shvetank Bhatt,Aayush Sehgal,Saurabh Bhatia,Sukhbir Singh,Neelam Sharma,Shantini Vijayabalan,Vasanth Raj Palanimuthu,Suprava Das,Rajwinder Kaur,Lotfi Aleya,Simona Bungau +14 more
TL;DR: In this paper , the effects of 19 hydrolysable tannins on the SARS-CoV-2 were theoretically reviewed and analyzed utilizing the molecular operating surroundings for their C-Like protease 3CLpro catalytic dyad residues Angiotensin converting enzyme-2.
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