Cannabis sativa: The Plant of the Thousand and One Molecules
TLDR
Prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.Abstract:
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cultures. Additionally, an entire section is devoted to hemp trichomes, in the light of their importance as phytochemical factories. Ultimately, prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.read more
Citations
More filters
Journal ArticleDOI
Cannabis sativa-based oils against aluminum-induced neurotoxicity
Carla Alves,Wagner Antonio Tamagno,Ana Paula Vanin,Aline Pompermaier,Leonardo José Gil Barcellos +4 more
TL;DR: In this paper , the potential effect of two different doses of CBD-and THC-rich based oils against Al-induced toxicity, in the zebrafish model, was evaluated by behavioral biomarkers of the novel tank test (NTT) and social preference test (SPT).
Patent
Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
TL;DR: In this paper, a method for controlling cannabinoid synthesis in a cell or plant or plant part comprising same is provided, comprising modulating expression in the cell of at least one polypeptide comprising an amino acid sequence at least 95 % identical to SEQ ID NO: 1-15 and 8-86.
Journal ArticleDOI
Relationship Between Recreational Cannabis Use and Helicobacter pylori Infection
TL;DR: In this article , the authors evaluated the association between cannabis use and Helicobacter Pylori infection (HPI) among a representative community sample and found that recreational cannabis use is associated with diminished risk of HPI.
Journal ArticleDOI
Fast and reliable profiling of cannabinoids in seized samples using the method of HPLC–DAD followed by chemometrics
Sabrina Laíz Büttenbender,Graciela Carlos,Martin Steppe,Rafael S. Ortiz,Renata Pereira Limberger,Andreas Sebastian Loureiro Mendez +5 more
TL;DR: This paper presents a work involving the qualitative assessment of cannabinoids in different samples of cannabis and its derivatives from three different seizures by the Federal Police of Brazil.
Journal ArticleDOI
Biological properties and therapeutic applications of cannabidiol
Elanne Costa Glória,Adriana Idalina Torcato de Oliveira,Juliana Fonseca Moreira da Silva,Raphael Sanzio Pimenta +3 more
TL;DR: An integrative review of CBD and its potential benefits for human health confirmed CBD therapeutic actions in diseases such as schizophrenia, anxiety, epilepsy and motor disorders such as Parkinson's disease, Alzheimer’s disease, multiple sclerosis, neuropathic pain, childhood convulsive disorders, Lennox-Gastaut and Dravet syndromes.
References
More filters
Journal ArticleDOI
Natural Products as Sources of New Drugs over the Last 25 Years
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003 and is able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame.
Journal ArticleDOI
Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of the three prior reviews and adds a new designation, "natural product botanical" or "NB", to cover those botanical "defined mixtures" that have now been recognized as drug entities by the FDA and similar organizations.
Journal ArticleDOI
In vitro: Response of plant growth regulators and antimalformins on conidia germination of Fusarium mangiferae and incidence of mango malformation
TL;DR: The present findings do not authenticate the involvement of F. mangiferae in the disease, however hormonal imbalance, most probably ethylene, might be responsible for deformed functional morphology of panicle and a signal transduction mechanism of stress-stimulated ethylene imbalance causing physio-morphological changes in reproductive organs of mango flower and thereby failure of fertilization and fruit set needs to be investigated.
Journal ArticleDOI
Adverse Health Effects of Marijuana Use
TL;DR: As marijuana use becomes legal in some states, the dominant public opinion is that marijuana is a harmless source of mood alteration, but enough information is available to cause concern.
Journal ArticleDOI
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
TL;DR: A comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy is provided.
Related Papers (5)
Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects
Chemical constituents of marijuana: The complex mixture of natural cannabinoids
Mahmoud A. ElSohly,Desmond Slade +1 more