Cannabis sativa: The Plant of the Thousand and One Molecules
TLDR
Prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.Abstract:
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cultures. Additionally, an entire section is devoted to hemp trichomes, in the light of their importance as phytochemical factories. Ultimately, prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.read more
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Patent
High level in vivo biosynthesis and isolation of water-soluble cannabinoids in plant systems
TL;DR: In this paper, the inventive technology relates to systems and methods for enhanced in vivo production, accumulation and modification of cannabinoids in a whole plant, or a cell suspension culture system, in one embodiment, the invention may include enhanced in-vivo biosynthesis of chemically-modified water-soluble cannabinoids.
Journal ArticleDOI
Quality of Oil Pressed from Hemp Seed Varieties: ‘Earlina 8FC’, ‘Secuieni Jubileu’ and ‘Finola’
Wojciech Golimowski,Mirosława Teleszko,Damian Marcinkowski,Dominik Kmiecik,Anna Grygier,Andrzej Kwaśnica +5 more
TL;DR: In this paper , a study was conducted to characterize the seeds of different types of hemp (Cannabis sativa L.) varieties: "Finola" (FIN-314), "Earlina 8FC", and "Secuieni Jubileu" (S. Jubileus), and cold and hot pressed oils were prepared from each seed.
Book ChapterDOI
Hemp Fibers for Wastewater Treatment
TL;DR: In this paper, the authors report relevant published researches dealing with new sorbents based on hemp fibers applied in batch and dynamic systems for the removal of pollutants from environmental aqueous media.
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Regulatory sampling of industrial hemp plant samples (Cannabis sativa L.) using UPLC-MS/MS method for detection and quantification of twelve cannabinoids
Erin C. Berthold,Rui Yang,Abhisheak Sharma,Shyam H. Kamble,Siva Rama Raju Kanumuri,Tamara I. King,Raluca Popa,Jim Freeman,Zachary T. Brym,Bonnie A. Avery,Christopher R. McCurdy +10 more
TL;DR: A robust analytical method was developed to analyze hemp samples in a trial regulatory study, which indicates that the way hemp is sampled and analyzed may influence the legality of a crop, which could have negative economic and legal consequences.
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