Cannabis sativa: The Plant of the Thousand and One Molecules
TLDR
Prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.Abstract:
Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cultures. Additionally, an entire section is devoted to hemp trichomes, in the light of their importance as phytochemical factories. Ultimately, prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.read more
Citations
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Understanding Cannabis sativa L.: Current Status of Propagation, Use, Legalization, and Haploid-Inducer-Mediated Genetic Engineering
TL;DR: The beneficial and harmful effects of the prominent phytocannabinoids are described and status of the studies on heterologous synthesis of phytcannabinoids in different biological systems are provided.
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Effect of Potassium (K) Supply on Cannabinoids, Terpenoids and Plant Function in Medical Cannabis
Avia Saloner,Nirit Bernstein +1 more
TL;DR: In this paper , the authors evaluate the hypothesis that potassium supply, which is known to substantially affect plant development and function, affects the secondary metabolism of the cannabis plant and show that the concentrations of most cannabinoids and terpenoids declined with the elevation of K supply, thus supporting the hypothesis.
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Cannabis Vaping-Induced Acute Pulmonary Toxicity: Case Series and Review of Literature
Sreedhar Adapa,Vijay Gayam,Venu Madhav Konala,Srinadh Annangi,Mina P Raju,Vishnu Bezwada,Christine McMillan,Hussain Dalal,Amrendra Mandal,Srikanth Naramala +9 more
TL;DR: A review analysis of the literature published on acute respiratory failure from vaping cannabis oil found the different available formulations of cannabis oil and key ingredients responsible for the vaping-associated lung injury.
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Distribution of cell-wall polysaccharides and proteins during growth of the hemp hypocotyl.
Marc Behr,Claudia Faleri,Jean-Francois Hausman,Sébastien Planchon,Jenny Renaut,Giampiero Cai,Gea Guerriero +6 more
TL;DR: The immuno-ultrastructural investigation localized cell-wall polysaccharides of bast fibers during hemp hypocotyl growth, and for the first time, the localization of a peroxidase and laccase is provided in textile hemp.
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A Cup of Hemp Coffee by Moka Pot from Southern Italy: An UHPLC-HRMS Investigation.
TL;DR: This study opens up a new concrete possibility to exploit hemp processing by-products in order to obtain drinks with high added value and paves the way for further in vitro and in vivo investigations aimed at promoting their benefits for human health.
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