Journal ArticleDOI
CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF
Craig A. Smith,Hans Juergen Gruss,Terri Davis,Dirk K. Anderson,Terry Farrah,Elizabeth Baker,Grant R. Sutherland,Camilynn I. Brannan,Neal G. Copeland,Nancy A. Jenkins,Kenneth H. Grabstein,Brian Gliniak,Ian B. McAlister,William C. Fanslow,Mark R. Alderson,Ben A. Falk,Steve Gimpel,Steven Gillis,Wenie S. Din,Raymond G. Goodwin,Richard J. Armitage +20 more
TLDR
The recombinant human ligand enhances the proliferation of CD3-activated T cells yet induces differential responses, including cell death, in several CD30+ lymphoma-derived clones.About:
This article is published in Cell.The article was published on 1993-07-02. It has received 569 citations till now. The article focuses on the topics: CD30 & T cell.read more
Citations
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Identification and characterization of a new member of the TNF family that induces apoptosis
Steven R. Wiley,Ken Schooley,Pamela J. Smolak,Wenie S. Din,Chang-Pin Huang,Jillian Nicholl,Grant R. Sutherland,Terri Davis Smith,Charles Rauch,Craig A. Smith,Raymond G. Goodwin +10 more
TL;DR: A novel tumor necrosis factor (TNF) family member has been cloned and characterized, and the TRAIL gene is located on chromosome 3 at position 3q26, which is not close to any other known TNF ligand family members.
Journal ArticleDOI
Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family
TL;DR: Northern hybridization revealed that Fas ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T cell-mediated cytotoxicity and in several nonlymphoid tissues, such as testis.
Journal ArticleDOI
Fusion of a Kinase Gene, ALK, to a Nucleolar Protein Gene, NPM, in Non-Hodgkin's Lymphoma
Stephan W. Morris,Mark N. Kirstein,Marcus B. Valentine,KG Dittmer,KG Dittmer,David N. Shapiro,David N. Shapiro,D. L. Saltman,AT Look,AT Look +9 more
TL;DR: In the predicted hybrid protein, the amino terminus of nucleophosmin (NPM) is linked to the catalytic domain of anaplastic lymphoma kinase (ALK), and unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas.
Journal ArticleDOI
The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
Journal ArticleDOI
Tnf/tnfr family members in costimulation of t cell responses
TL;DR: This review focuses on CD27, 4-1BB, OX40, HVEM, CD30, and GITR, all of which can have costimulatory effects on T cells, and shows promise for several therapeutic applications, including cancer, infectious disease, transplantation, and autoimmunity.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
TL;DR: The sequence CCAGCCAUG (G) thus emerges as a consensus sequence for eukaryotic initiation sites, and the extent to which the ribosome binding site in a given mRNA matches the -1 to -5 consensus sequence varies.
Journal ArticleDOI
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.
Naoto Itoh,Shin Yonehara,Ai Ishii,Minako Yonehara,Sei Ichi Mizushima,Masazumi Sameshima,Atsushi Hase,Yoshiyuki Seto,Shigekazu Nagata +8 more
TL;DR: Complementary DNAs encoding the cell surface antigen Fas were isolated from a cDNA library of human T cell lymphoma KT-3 cells and revealed that the molecule coding for the Fas antigen determinant is a 319 amino acid polypeptide with a single transmembrane domain.
Journal ArticleDOI
The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells.
Harald Stein,D Y Mason,Johannes Gerdes,N O'Connor,J. S. Wainscoat,Gorm Pallesen,K C Gatter,B Falini,Georges Delsol,Hilmar Lemke,R Schwarting,Karl Lennert +11 more
TL;DR: Results obtained indicate that Ki-1 antigen is an inducible lymphoid-associated molecule that identifies a group of hitherto poorly characterized normal and neoplastic large lymphoid cells in Hodgkin's disease and Disorders in which only a minority of cells express Ki- 1 antigen probably represent lesions in whichonly some of the abnormal cells have transformed into an "activation state.