Journal ArticleDOI
Colonic inflammation in Parkinson's disease.
David Devos,Thibaud Lebouvier,Bernard Lardeux,Bernard Lardeux,Mandy Biraud,Tiphaine Rouaud,Tiphaine Rouaud,Hélène Pouclet,Emmanuel Coron,Stanislas Bruley des Varannes,Philippe Naveilhan,Philippe Naveilhan,Jean-Michel Nguyen,Michel Neunlist,Michel Neunlist,Pascal Derkinderen +15 more
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TLDR
Findings provide evidence that enteric inflammation occurs in Parkinson's disease and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease.About:
This article is published in Neurobiology of Disease.The article was published on 2013-02-01. It has received 446 citations till now. The article focuses on the topics: Glial fibrillary acidic protein & Parkinson's disease.read more
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Journal ArticleDOI
Exploring the multifactorial aspects of Gut Microbiome in Parkinson’s Disease
S Pavan,Arvind N Prabhu,Sankar Prasad Gorthi,Bhabatosh Das,Ankur Mutreja,Vignesh Shetty,Thandavarayan Ramamurthy,Mamatha Ballal +7 more
TL;DR: In this paper , a review recapitulates the gut microbiome associated with PD severity, duration, motor and non-motor symptoms, and antiparkinsonian treatment from recent literature and emphasises on implications of the prebiotic, probiotic, faecal microbiota transplantation, and dietary interventions as alternative treatments in modulating the disease symptoms in PD.
Journal ArticleDOI
Microbiota in Health and Disease-Potential Clinical Applications.
Matthias Laudes,Corinna Geisler,Nathalie Rohmann,Jildau Bouwman,Tobias Pischon,Kristina Schlicht +5 more
TL;DR: In this paper, a review aims to provide examples for future clinical applications in various entities and to suggest bacterial species and/or microbial effector molecules as potential targets for intervention studies.
Journal ArticleDOI
Are neurodegenerative diseases associated with an increased risk of inflammatory bowel disease? A two-sample Mendelian randomization study
TL;DR: The MR study corroborated a causal association between genetically predicted PD and IBD but did not support a causal effect of genetically predicted AD on IBD.
Book ChapterDOI
Gastrointestinal dysfunction in Parkinson's disease
Jonathan Timpka,Per Odin +1 more
TL;DR: The epidemiology and pathophysiology of gastrointestinal dysfunction in Parkinson's disease is reviewed, the current disease-specific knowledge on the role of microbiota and the brain-gut-microbiota axis is presented and an overview of the treatment options is presented.
Journal ArticleDOI
The link between the gut microbiota and Parkinson's Disease: A systematic mechanism review with focus on α-synuclein transport.
TL;DR: In this article, a systematic literature search was performed to investigate whether the neurodegenerative cascade begins in the gut; mediated by gut dysbiosis and retrograde transport of α-synuclein.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TL;DR: The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
TL;DR: The detected large numbers of HLA-DR-positive reactive microglia (macrophages) in the substantia nigra of all cases studied with Parkinson's disease and parkinsonism and suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.
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Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more