Journal ArticleDOI
Colonic inflammation in Parkinson's disease.
David Devos,Thibaud Lebouvier,Bernard Lardeux,Bernard Lardeux,Mandy Biraud,Tiphaine Rouaud,Tiphaine Rouaud,Hélène Pouclet,Emmanuel Coron,Stanislas Bruley des Varannes,Philippe Naveilhan,Philippe Naveilhan,Jean-Michel Nguyen,Michel Neunlist,Michel Neunlist,Pascal Derkinderen +15 more
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TLDR
Findings provide evidence that enteric inflammation occurs in Parkinson's disease and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease.About:
This article is published in Neurobiology of Disease.The article was published on 2013-02-01. It has received 446 citations till now. The article focuses on the topics: Glial fibrillary acidic protein & Parkinson's disease.read more
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Journal ArticleDOI
How does parkinson's disease begin? Perspectives on neuroanatomical pathways, prions, and histology.
TL;DR: It is concluded that the dual‐hit hypothesis remains a potential explanation for PD pathogenesis, but several issues need to be resolved before more firm conclusions can be drawn.
Journal ArticleDOI
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease.
Chrysoula Marogianni,Maria Sokratous,Efthimios Dardiotis,Georgios M. Hadjigeorgiou,Dimitrios P. Bogdanos,Georgia Xiromerisiou +5 more
TL;DR: The binary role of microglia activation in the pathophysiology of PD is highlighted, both neuroprotective and neuromodulatory, and how the expression of several cytokines implicated in dopaminergic neurons (DA) degeneration could be used as biomarkers for PD is presented.
Journal ArticleDOI
Longitudinal Analysis of Fecal Microbiome and Pathologic Processes in a Rotenone Induced Mice Model of Parkinson’s Disease
TL;DR: It is reported that chronically oral administered rotenone caused gastrointestinal dysfunction and microbiome dysbiosis prior to motor dysfunction and central nervous system (CNS) pathology and brought a new insight in the pathogenesis of PD.
Journal ArticleDOI
Parkinson's disease and the gastrointestinal microbiome
Michal Lubomski,Ai Huey Tan,Shen-Yang Lim,Andrew J. Holmes,Ryan L. Davis,Carolyn M. Sue,Carolyn M. Sue +6 more
TL;DR: Evidence linking GM changes with PD is reviewed, highlighting mechanisms supportive of pathological α-synuclein spread and intestinal inflammation in PD and roles of GM modulating therapies including probiotics and faecal microbiota transplantation are discussed.
Journal ArticleDOI
The Role of Neuroinflammation in Dementias
Giuseppe Pasqualetti,Giuseppe Pasqualetti,David J. Brooks,David J. Brooks,Paul Edison,Paul Edison +5 more
TL;DR: The scientific literature on neuroinflammation related to the most common neurodegenerative dementias (AD, PDD, FTD and LBD) is reviewed, focussing on the possible molecular mechanisms and the available clinical evidence.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TL;DR: The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
TL;DR: The detected large numbers of HLA-DR-positive reactive microglia (macrophages) in the substantia nigra of all cases studied with Parkinson's disease and parkinsonism and suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.
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