Journal ArticleDOI
Colonic inflammation in Parkinson's disease.
David Devos,Thibaud Lebouvier,Bernard Lardeux,Bernard Lardeux,Mandy Biraud,Tiphaine Rouaud,Tiphaine Rouaud,Hélène Pouclet,Emmanuel Coron,Stanislas Bruley des Varannes,Philippe Naveilhan,Philippe Naveilhan,Jean-Michel Nguyen,Michel Neunlist,Michel Neunlist,Pascal Derkinderen +15 more
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TLDR
Findings provide evidence that enteric inflammation occurs in Parkinson's disease and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease.About:
This article is published in Neurobiology of Disease.The article was published on 2013-02-01. It has received 446 citations till now. The article focuses on the topics: Glial fibrillary acidic protein & Parkinson's disease.read more
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Journal ArticleDOI
Aszensionshypothese beim idiopathischen Parkinson-Syndrom
TL;DR: Patienten with idiopathischem Parkinson-Syndrom durchlaufen verschiedene klinische Stadien, wobei nicht-motorische Symptome insbesondere die prodromale Phase der Parkinson-Erkrankung bestimmen, wahrend die motorischen Kardinalsymptome wie die Bradykinese with Rigiditat, Ruhetremor oder posturaler Instabilitat
Journal ArticleDOI
Peripheral Neuroprotective and Immunomodulatory Effects of 5α-Reductase Inhibitors in Parkinson’s Disease Models
Andrée Poirier,Mélissa Côté,Hend Jarras,Nadhir Litim,Jérôme Lamontagne-Proulx,Sara Al-Sweidi,Marc Morissette,Asmaa Lachhab,Martin Pelletier,Thérèse Di Paolo,Denis Soulet +10 more
TL;DR: Results indicate that dutasteride treatment prevents enteric neuronal damages in the MPTP mouse model, at least in part through anti-inflammatory and mitochondrial effects, suggesting that drug repurposing of dutasterside might be a promising avenue to treat enteric neuroinflammation in early PD.
Journal ArticleDOI
Improvement effect of acupuncture on locomotor function in Parkinson disease via regulating gut microbiota and inhibiting inflammatory factor release
TL;DR: Acupuncture intervention can improve locomotor function, reduce α-synuclein aggregation, inflammatory factors expression, and increase Akt signaling pathway in PD mice, and suggests that acupuncture intervention can protect PD model mice probably by regulating intestinal flora and activating AkT signaling pathway.
Book ChapterDOI
Enteric Glial Cells: Implications in Gut Pathology
TL;DR: This chapter focuses on the current understanding ofEnteric glial physiology and how enteric glia contrib- ute to, or are altered by, pathological events in the gut.
Journal ArticleDOI
Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s disease
Amica C. Müller-Nedebock,Marieke C. J. Dekker,Matthew J. Farrer,Nobutaka Hattori,Shen-Yang Lim,George D. Mellick,Irena Rektorová,Mohamed Salama,Artur Francisco Schumacher Schuh,A. Jon Stoessl,Carolyn M. Sue,Ai Huey Tan,Christine Klein,Soraya Bardien +13 more
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TL;DR: The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
TL;DR: The detected large numbers of HLA-DR-positive reactive microglia (macrophages) in the substantia nigra of all cases studied with Parkinson's disease and parkinsonism and suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.
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Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more