Journal ArticleDOI
Colonic inflammation in Parkinson's disease.
David Devos,Thibaud Lebouvier,Bernard Lardeux,Bernard Lardeux,Mandy Biraud,Tiphaine Rouaud,Tiphaine Rouaud,Hélène Pouclet,Emmanuel Coron,Stanislas Bruley des Varannes,Philippe Naveilhan,Philippe Naveilhan,Jean-Michel Nguyen,Michel Neunlist,Michel Neunlist,Pascal Derkinderen +15 more
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TLDR
Findings provide evidence that enteric inflammation occurs in Parkinson's disease and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease.About:
This article is published in Neurobiology of Disease.The article was published on 2013-02-01. It has received 446 citations till now. The article focuses on the topics: Glial fibrillary acidic protein & Parkinson's disease.read more
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Gut Microbiota and Disorders of the Central Nervous System
TL;DR: An overview of the possible involvement of the microbiota-gut-brain axis in the pathogenesis of diseases of the central nervous system is provided, with a special focus on key issues and common misjudgments on the potential contribution of specific microorganisms.
Journal ArticleDOI
Parkinson's Disease and the Gut: Future Perspectives for Early Diagnosis.
TL;DR: Detailed analyses of patient biopsies and autopsies as well as animal models of neuropathological changes characteristic of PD provided important information on the pathology or treatment of PD symptoms, but presently is not clarified the specific tissue in the GIT where the pathological processes associated with PD is initiated.
Journal ArticleDOI
Involvement of Enteric Glia in Small Intestine Neuromuscular Dysfunction of Toll-Like Receptor 4-Deficient Mice.
Silvia Cerantola,Valentina Caputi,Valentina Caputi,Ilaria Marsilio,Manuela Ridolfi,Sofia Faggin,Michela Bistoletti,Cristina Giaroni,Maria Cecilia Giron +8 more
TL;DR: Findings show the involvement of EGCs in the alterations of ENS architecture and in the increased purinergic and nitrergic-mediated relaxation, determining gut dysmotility in TLR4−/− mice.
Journal ArticleDOI
Leaky gut, dysbiosis, and enteric glia activation: the trilogy behind the intestinal origin of Parkinson's disease.
TL;DR: Recent evidence showing enteric glia involvement triggering intestinal neuroinflammation in the asymptomatic stage of Parkinson's disease is summarized and improvements in the therapeutic approach that could be achieved by targeting these glial cells are summarized.
Journal ArticleDOI
Diet and medical foods in Parkinson’s disease
Klaus W. Lange,Yukiko Nakamura,Ning Chen,Jianjun Guo,Shigehiko Kanaya,Katharina M. Lange,Shiming Li +6 more
TL;DR: High quality randomized controlled trials need to be conducted in order to evaluate whether these food-based strategies have symptomatic efficacy or the potential to delay the progression of PD.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TL;DR: The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
TL;DR: The detected large numbers of HLA-DR-positive reactive microglia (macrophages) in the substantia nigra of all cases studied with Parkinson's disease and parkinsonism and suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.
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Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more