Journal ArticleDOI
Colonic inflammation in Parkinson's disease.
David Devos,Thibaud Lebouvier,Bernard Lardeux,Bernard Lardeux,Mandy Biraud,Tiphaine Rouaud,Tiphaine Rouaud,Hélène Pouclet,Emmanuel Coron,Stanislas Bruley des Varannes,Philippe Naveilhan,Philippe Naveilhan,Jean-Michel Nguyen,Michel Neunlist,Michel Neunlist,Pascal Derkinderen +15 more
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TLDR
Findings provide evidence that enteric inflammation occurs in Parkinson's disease and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease.About:
This article is published in Neurobiology of Disease.The article was published on 2013-02-01. It has received 446 citations till now. The article focuses on the topics: Glial fibrillary acidic protein & Parkinson's disease.read more
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Book ChapterDOI
Prion-like propagation of pathology in Parkinson disease.
TL;DR: How the findings that α-synuclein pathology spreads throughout the nervous system has revolutionized the authors' understanding about Parkinson disease pathogenesis and resulted in the development of novel therapeutic strategies to halt disease progression is discussed.
Journal ArticleDOI
Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson’s Disease
Tobias Hegelmaier,Marco Lebbing,Alexander Duscha,Laura Tomaske,Lars Tönges,Jacob Bak Holm,Henrik Nielsen,Sören Gatermann,Horst Przuntek,Aiden Haghikia +9 more
TL;DR: Dietary intervention and bowel cleansing may provide an additional non-pharmacologic therapeutic option for PD patients and a significant association between the gut microbiome diversity and the UPDRS III and the abundance of Ruminococcaceae is observed.
Journal ArticleDOI
Causes and Consequences of Degeneration of the Dorsal Motor Nucleus of the Vagus Nerve in Parkinson's Disease
TL;DR: Better understanding of the DMV and vagus nerve may provide insight into PD pathogenesis and a neural highway with direct brain access that could be harnessed for novel therapeutic interventions.
Journal ArticleDOI
Fecal Calprotectin as a Marker of the Gut Immune System Activation Is Elevated in Parkinson's Disease.
Agata Mulak,Magdalena Koszewicz,Magdalena Panek-Jeziorna,Ewa Koziorowska-Gawron,Sławomir Budrewicz +4 more
TL;DR: The evaluation of fecal calprotectin level may be a useful tool to detect the signs of gut immune system activation present in a remarkable number of PD patients, also in the early stage of the disease.
Journal ArticleDOI
Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice.
Yuki Kishimoto,Wandi Zhu,Waki Hosoda,Jyoti Misra Sen,Jyoti Misra Sen,Mark P. Mattson,Mark P. Mattson +6 more
TL;DR: It is reported that chronic mild focal intestinal inflammation accelerates the age of disease onset in α-synuclein mutant PD mice and interventions that reduce gut inflammation may prove beneficial in the prevention and treatment of PD.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TL;DR: The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
TL;DR: The detected large numbers of HLA-DR-positive reactive microglia (macrophages) in the substantia nigra of all cases studied with Parkinson's disease and parkinsonism and suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.
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Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more